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公开(公告)号：EP3241826A2
公开(公告)日：2017-11-08
申请号：EP17174350.3
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：EP3929187A2
公开(公告)日：2021-12-29
申请号：EP21187758.4
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：EP3613734A3
公开(公告)日：2020-03-25
申请号：EP19199941.6
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：EP3929187A3
公开(公告)日：2022-02-16
申请号：EP21187758.4
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：EP2402313B1
公开(公告)日：2016-08-24
申请号：EP10746231.9
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D207/34 , C07D207/333 , C07D207/36 , C07D401/12
CPC分类号： C07D207/337 , C07C225/14 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
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公开(公告)号：EP3015488A1
公开(公告)日：2016-05-04
申请号：EP14818491.4
申请日：2014-06-25
CPC分类号： C08G69/48 , A61K39/39 , A61K47/34 , A61K2039/55555 , A61K2039/6093 , C08G69/08 , C08G69/10 , C08L77/04
摘要： The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof ( e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.
摘要翻译： 本发明涉及聚氨基酸或其盐与疏水伯胺化合物或其盐（例如聚（γ-谷氨酸）的接枝共聚物（γ-PGA-PAE））的接枝共聚物， （γ-PGA）和苯丙氨酸乙酯（PAE）），聚（氨基酸）或其盐与疏水性伯胺化合物或其盐的离子化接枝共聚物，含有离子化接枝共聚物的纳米粒子， 方法。 以这种方式获得的纳米颗粒可用作生产疫苗的佐剂。
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公开(公告)号：EP2402313A1
公开(公告)日：2012-01-04
申请号：EP10746231.9
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D207/34 , C07D207/333 , C07D207/36 , C07D401/12
CPC分类号： C07D207/337 , C07C225/14 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
摘要翻译： 本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。 本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应，得到化合物（Ⅵ）， 并使化合物（VI）进行胺化反应。
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公开(公告)号：EP3613734A2
公开(公告)日：2020-02-26
申请号：EP19199941.6
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：EP2921499B1
公开(公告)日：2020-01-22
申请号：EP13854700.5
申请日：2013-11-13
IPC分类号： C07H19/073 , C07H19/067 , C07H21/04 , C07H19/167 , C07H1/00 , C07H21/00
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公开(公告)号：EP3241826B1
公开(公告)日：2019-10-30
申请号：EP17174350.3
申请日：2010-02-24
发明人： IKEMOTO, Tomomi , MIZUFUNE, Hideya , NAGATA, Toshiaki , SERA, Misayo , FUKUDA, Naohiro , YAMASAKI, Takeshi
IPC分类号： C07D401/12
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