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公开(公告)号:EP1896436A2
公开(公告)日:2008-03-12
申请号:EP06759801.1
申请日:2006-05-10
发明人: BRESSI, Jerome, C. , BROWN, Jason, W. , GANGLOFF, Anthony, R. , STAFFORD, Jeffrey, A. , VU, Phong, H.
IPC分类号: C07D285/24 , C07D239/80 , C07D417/12 , C07D417/06
CPC分类号: C07D513/04 , C07D239/80 , C07D285/24 , C07D417/04 , C07D417/06 , C07D417/12
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of : formula (I) and formula (II) wherein the variables are as defined herein.
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公开(公告)号:EP1824831A2
公开(公告)日:2007-08-29
申请号:EP05857114.2
申请日:2005-12-16
发明人: BRESSI, Jerom, C. , BROWN, Jason, W. , GANGLOFF, Anthony, R. , JENNINGS, Andrew, J. , KALDOR, Stephen, W. , SKENE, Robert, J. , STAFFORD, Jeffrey, A. , VU, Phong, H.
IPC分类号: C07D235/06 , C07D235/26 , C07D233/32 , C07D263/58 , C07D277/68 , C07D235/30 , C07D471/04 , C07D235/28 , C07D277/70 , C07D401/12 , C07D401/04 , C07D409/06 , C07D409/04 , C07D403/04 , C07D405/04
CPC分类号: C07D235/06 , C07D235/26 , C07D263/38 , C07D263/58 , C07D277/68 , C07D277/72 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formula: wherein the variables are as defined herein.
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公开(公告)号:EP1608628A2
公开(公告)日:2005-12-28
申请号:EP04757631.9
申请日:2004-03-17
发明人: BRESSI, Jerome, C. , BROWN, Jason, W. , CAO, Sheldon, X. , GANGLOFF, Anthony, R. , JENNINGS, Andrew, J. , STAFFORD, Jeffrey, A. , VU, Phong, H. , XIAO, Xiao-Yi
IPC分类号: C07D235/18 , A61K31/4184
CPC分类号: C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10
摘要: Compounds that may be used to inhibit histone deacetylase having the formula (I) or formula (II) wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.
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