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公开(公告)号：EP2957423B1
公开(公告)日：2018-01-17
申请号：EP15179184.5
申请日：2007-10-29
IPC分类号： B32B9/00 , B82B1/00 , B82B3/00 , C08J5/18 , C08J7/12 , A61K9/00 , A61K9/70 , B32B37/02 , B32B38/10 , C12N5/00
CPC分类号： B32B37/02 , A61K9/0014 , A61K9/70 , A61K9/7007 , B32B38/10 , C08J5/18 , C08J7/12 , C12N5/0068 , C12N2535/10 , Y10T156/10 , Y10T428/31504
摘要： A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then (d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body; (e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent. A method for preparing a thin film molecular structure having a functional substance on the face (A surface) and reverse face (B surface) of the film is offered through the above process.
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公开(公告)号：EP2957423A1
公开(公告)日：2015-12-23
申请号：EP15179184.5
申请日：2007-10-29
IPC分类号： B32B9/00 , B82B1/00 , B82B3/00 , C08J5/18 , C08J7/12 , A61K9/00 , A61K9/70 , B32B37/02 , B32B38/10 , C12N5/00
CPC分类号： B32B37/02 , A61K9/0014 , A61K9/70 , A61K9/7007 , B32B38/10 , C08J5/18 , C08J7/12 , C12N5/0068 , C12N2535/10 , Y10T156/10 , Y10T428/31504
摘要： Disclosed is a thin film-like polymer structure which is obtained by the steps described below and has a functional substance on the front surface (surface A) and the back surface (surface B). Also disclosed is a method for preparing such a thin film-like polymer structure. (a) a step wherein polyfunctional molecules are adsorbed on an arbitrarily shaped region at the interface of a base with a liquid phase (b) a step wherein a polymer thin film is formed by polymerizing and/or crosslinking the adsorbed polyfunctional molecules (c) a step wherein a functional substance is bonded onto the surface A of the thus-formed thin film (d) a step wherein a soluble supporting film is formed on the thin film, and then the thin film and the supporting film are removed from the base (e) a step wherein a functional substance is bonded onto the surface B of the thin film, and then the supporting film is dissolved by a solvent.
摘要翻译： 公开了一种薄膜状聚合物结构，其通过下述步骤获得，并且在前表面（表面A）和背面（表面B）上具有功能性物质。 还公开了制备这种薄膜状聚合物结构的方法。 （a）其中多官能分子吸附在碱与液相界面处的任意形状区域（b）通过使吸附的多官能分子（c）聚合和/或交联而形成聚合物薄膜的步骤， 将功能性物质结合到如此形成的薄膜（d）的表面A上的步骤，其中在薄膜上形成可溶性支撑膜，然后从基底去除薄膜和支撑膜 （e）将功能性物质结合到薄膜的表面B上，然后通过溶剂使支持膜溶解的工序。
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公开(公告)号：EP2082869B1
公开(公告)日：2015-09-16
申请号：EP07831170.1
申请日：2007-10-29
CPC分类号： B32B37/02 , A61K9/0014 , A61K9/70 , A61K9/7007 , B32B38/10 , C08J5/18 , C08J7/12 , C12N5/0068 , C12N2535/10 , Y10T156/10 , Y10T428/31504
摘要： A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then (d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body; (e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent. A method for preparing a thin film molecular structure having a functional substance on the face (A surface) and reverse face (B surface) of the film is offered through the above process.
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公开(公告)号：EP3231457A1
公开(公告)日：2017-10-18
申请号：EP15867856.5
申请日：2015-12-04
发明人： HOCHI, Motonori , SEKIDO, Yuki , SAITO, Akihiro , TAKEOKA, Shinji , OHTSUBO, Shinya , HINOKI, Akinari , KINOSHITA, Manabu
CPC分类号： A61L15/28 , A61L15/24 , A61L15/26 , A61L31/042 , A61L31/048 , A61L31/06 , B32B27/00 , B32B27/32 , C08L5/08 , C08L67/04
摘要： The purpose of the present invention is to provide a laminated film that is highly biocompatible and easy to handle, has good pasting ability and contact to an organ tissue and rarely induces infections. The laminated film provided by the present invention, which comprises a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle, and, when stuck to an adherend with curved surface, the laminated film shows excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. Moreover, the acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs, etc. Thus, the laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
摘要翻译： 本发明的目的是提供一种生物相容性高，操作容易，粘贴性良好，与器官组织接触，极少引起感染的层压薄膜。 由聚乳酸系树脂层和层压在聚乳酸系树脂层侧的一个或多个乙酰化透明质酸层构成的本发明提供的层压膜柔韧性高，易于处理， 粘附到具有曲面的被粘物上时，由于乙酰化透明质酸层可以容易地用聚乳酸系树脂层中的水溶液除去，因此对被粘物显示优异的追随性，粘附性和涂布性， 薄膜形状。 此外，乙酰化透明质酸和聚乳酸类树脂是可生物降解的，因此，该层压膜与皮肤和器官如内脏器官等高度相容。因此，该层压膜最佳地可用作外用皮肤材料 应用如伤口涂层材料，粘合抑制剂和皮肤护理制品。
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公开(公告)号：EP3520825A1
公开(公告)日：2019-08-07
申请号：EP17856413.4
申请日：2017-09-29
发明人： SAITO, Akihiro , NAKANISHI, Megumi , TANAHASHI, Kazuhiro , ARAKANE, Toru , HOCHI, Motonori , SUZUKI, Ai , OKABAYASHI, Koji , TAKEOKA, Shinji , FUJIE, Toshinori , ISHIDUKA, Yuya , OHTSUBO, Shinya
摘要： This invention provides a material for adhesion prevention that can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-µm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-µm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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6.发明公开
公开(公告)号：EP3868740A1
公开(公告)日：2021-08-25
申请号：EP19872471.8
申请日：2019-10-17
发明人： TAKEOKA, Shinji , NAKAHARA, Keiko , NISHIURA, Mamoru , OTSUBO, Shinya , KURUMATANI, Hajimu , ARAKANE, Toru
IPC分类号： C07C233/05 , A61K31/225 , A61P7/04 , C07K5/00 , C07K7/00
摘要： An object of the present invention is to provide a carboxylic acid-type lipid that can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets, such as GPIb and H12, or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each comprising the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each comprising the carboxylic acid-type lipid, the lipid particle or the lipid membrane, and, in order to achieve the object, the present invention provides a carboxylic acid-type lipid selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle comprising the carboxylic acid-type lipid, a lipid membrane comprising the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each comprising the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
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公开(公告)号：EP3868413A1
公开(公告)日：2021-08-25
申请号：EP19873651.4
申请日：2019-10-17
发明人： TAKEOKA, Shinji , NAKAHARA, Keiko , NISHIURA, Mamoru , OTSUBO, Shinya , KURUMATANI, Hajimu , ARAKANE, Toru , TAKEDA, Masanobu , NAKAHARA, Makoto , OYAMA, Kumi
IPC分类号： A61L15/20 , A61K9/127 , A61K9/70 , A61K47/24 , A61K47/28 , A61K47/34 , A61K47/36 , A61L15/26 , A61L15/28 , A61L15/42 , A61L15/64
摘要： An object of the present invention is to provide a hemostatic material comprising a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets, such as GPIb and H12, and, in order to achieve the object, the present invention provides a hemostatic material (10) comprising a water-insoluble base (1) and a lipid supported on a surface of the base (2), wherein the lipid comprises one or two or more anionic lipids.
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公开(公告)号：EP3295966A1
公开(公告)日：2018-03-21
申请号：EP16792702.9
申请日：2016-05-11
发明人： HOCHI, Motonori , SEKIDO, Yuki , ITAGAKI, Ichiro , ARAKANE, Toru , OHTSUBO, Shinya , TAKEOKA, Shinji , MURATA, Atsushi , FUJII, Mao , ISHIZUKA, Yuya , SHOJI, Shuichi , MIZUNO, Jun , KASAHARA, Takashi
CPC分类号： C08J5/18 , A61K8/04 , A61K8/8117 , A61K8/8152 , A61K8/8176 , A61K8/85 , A61K8/86 , A61L15/22 , A61L15/225 , A61L15/24 , A61L15/26 , A61L31/00 , A61L31/041 , A61L31/048 , A61L31/06 , A61Q19/00 , C08J2325/06 , C08J2333/12 , C08J2367/04 , C08J2467/04 , C08L25/06 , C08L33/12 , C08L67/04
摘要： Provided are: a polymer film characterized in that the average film thickness T 0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm ≤ T 0 ≤ 1000 nm, (b) 0.1 µm ≤ L ≤ 500 µm, (c) 0.01 GPa ≤ E ≤ 4.3 GPa, (d) Δ = 1 - T 1 /T 2 , (e) 0.346E x 10 -9 - 1.499 -9 + 0.316. According to the present invention, a polymer film which is easy to handle and has excellent followability, coatability, adhesiveness, and adherence with respect to organ tissues; and a dispersion liquid and an agglomerate using the same can be provided.
摘要翻译： 本发明提供一种聚合物膜，其特征在于，沿着通过二维投影的重心的直线D使得聚合物膜的面积最大化的平均膜厚度T0满足方程（a），平均值 从重心到边缘的距离1的值满足方程（b），杨氏模量E满足方程（c），并且由方程（d）定义的厚度偏差Δ满足方程（e）; 以及使用其的分散液和团块。 （a）10nm≤T0≤1000nm，（b）0.1μm≤L≤500μm，（c）0.01GPa≤E≤4.3GPa，（d）Δ= 1 -T 1 / T 2，（e）0.346E x 10-9-1.499 <Δ<-0.073E×10-9 + 0.316。 根据本发明，提供一种易于处理且具有优异的追随性，涂布性，粘附性和对器官组织的粘附性的聚合物膜; 并且可以提供分散液和使用其的分散液。
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公开(公告)号：EP1785448B1
公开(公告)日：2011-03-02
申请号：EP05782124.1
申请日：2005-08-31
申请人： Takeoka, Shinji
CPC分类号： C08J5/18 , B82Y30/00 , Y10T428/31504
摘要： A thin-filmy polymeric structure obtained by the steps of: (a) adsorbing polyfunctional molecules onto that region on a substrate which is located at the interface between the substrate and a liquid phase and has any desired shape, (b) polymerizing and/or crosslinking the adsorbed polyfunctional molecules to form a thin film of a polymer, and (c) stripping the resultant thin film from the substrate.
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10.发明公开THIN FILM-LIKE POLYMER STRUCTURE AND METHOD FOR PREPARING THE SAME 有权FOLIENARTIGE POLYMERSTRUKTUR UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2082869A1
公开(公告)日：2009-07-29
申请号：EP07831170.1
申请日：2007-10-29
申请人： Takeoka, Shinji
CPC分类号： B32B37/02 , A61K9/0014 , A61K9/70 , A61K9/7007 , B32B38/10 , C08J5/18 , C08J7/12 , C12N5/0068 , C12N2535/10 , Y10T156/10 , Y10T428/31504
摘要： A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of:
(a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase;
(b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film;
(c) bonding a functional substance to the A surface of the formed thin film and then
(d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body;
(e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent.
A method for preparing a thin film molecular structure having a functional substance on the face (A surface) and reverse face (B surface) of the film is offered through the above process.摘要翻译： 一种薄膜聚合物结构体，其具有通过以下步骤获得的膜的表面（A表面）和反面（B面）上的官能物质：（a）使多官能分子吸附在任意形状的区域中 基体与液相之间的界面; （b）使吸附的多官能分子聚合和/或交联以形成聚合物薄膜; （c）将功能性物质结合到所形成的薄膜的A表面，然后（d）在其上形成可溶性载体膜; 将薄膜和可溶性支撑膜从基体体层剥离; （e）将与所述功能物质相同或不同的功能性物质与所述薄膜的B面接合，然后用溶剂溶解所述可溶性载体膜。 通过上述方法提供了在膜的表面（A表面）和反面（B面）上制备具有功能性物质的薄膜分子结构的方法。
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