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公开(公告)号：EP1420831A1
公开(公告)日：2004-05-26
申请号：EP02756736.1
申请日：2002-07-26
申请人： Targesome, Inc.
CPC分类号： A61K51/1234
摘要： Lipid constructs containing a chelator, a targeting entity, a detectable entity, and/or a therapeutic entity are provided, as well as methods relating to their use. The therapeutic or treatment entity may be associated with the lipid construct by covalent or non-covalent means. In some cases, the therapeutic or treatment entity is a radioisotope.
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公开(公告)号：EP1372739A2
公开(公告)日：2004-01-02
申请号：EP02713800.7
申请日：2002-03-08
申请人： Targesome, Inc.
发明人： BEDNARSKI, Mark, D. , DECHENE, Neal, Edward , PEASE, John, S. , WARTCHOW, Charles, Aaron , BRUNKE, Karen, J.
IPC分类号： A61K51/00
CPC分类号： A61K9/1273 , A61K47/6911 , A61K47/6913 , A61K51/1234 , A61K51/1237
摘要： Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.
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公开(公告)号：EP1401818A2
公开(公告)日：2004-03-31
申请号：EP02741784.9
申请日：2002-05-30
申请人： Targesome, Inc.
发明人： DANTHI, Narasimhan, S. , CHOI, Steven, H. , BEDNARSKI, Mark, David , WARTCHOW, Charles, Aaron , DECHENE, Neal, Edward , PEASE, John, S. , SHEN, Zhi, Min , ZHANG, Michael , TRULSON, Julie
CPC分类号： A61K51/1227 , A61K47/6907 , A61K47/6911 , A61K51/1234 , B82Y5/00
摘要： Targeted macromolecules comprising a linking carrier and more than one targeting entityare provided, as well as methods for their preparation and use. Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are also provided, as well as methods for their preparation and use.
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公开(公告)号：EP1330268A1
公开(公告)日：2003-07-30
申请号：EP01979715.8
申请日：2001-10-11
申请人： Targesome, Inc.
发明人： LI, King, Chuen , BEDNARSKI, Mark, David , WARTCHOW, Charles, Aaron , PEASE, John, S. , DECHENE, Neal, Edward , TRULSON, Julie , SHEN, Zhi, Min
IPC分类号： A61K51/00
CPC分类号： A61K49/0002 , A61K49/16 , A61K49/1812 , A61K51/1045 , A61K51/1237
摘要： Therapeutic and imaging agents which are comprised of a targeting entity, a therapeutic or treatment entity and a linking carrier are provided. The linking carrier imparts additional advantages to the therapeutic agents, which are not provided by conventional linking methods. Preferred agents of the present invention comprises a lipid construct, vesicle, liposome, or polymerized liposome. In some cases, the therapeutic or treatment entity is a radioisotope, chemotherapeutic agent, prodrug, toxin, or gene encoding a protein that exhibits cell toxicity. Preferably, the agent is further comprised of a stabilizing entity that imparts additional advantages to the therapeutic or imaging agent.
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