公开(公告)号：EP2783679B1

公开(公告)日：2018-07-18

申请号：EP12851387.6

申请日：2012-08-23

申请人： Original BioMedicals Co., Ltd.

发明人： WANG, Chau Hui ,  CHEN, Chia Hung ,  LIN, Johnson ,  CHEN, Jing Yi ,  LIAO, Wei Chuan

IPC分类号： A61K9/107 ,  A61K9/51 ,  A61K31/00 ,  A61K33/24 ,  A61K49/18 ,  A61K51/12 ,  A61K47/60 ,  A61K47/54 ,  A61K47/64 ,  A61K47/69 ,  A61P35/00

CPC分类号： A61K49/1809 ,  A61K9/1075 ,  A61K9/5115 ,  A61K9/5153 ,  A61K47/547 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6907 ,  A61K51/1227

摘要： This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.

公开(公告)号：EP0162724B1

公开(公告)日：1993-08-25

申请号：EP85303676.2

申请日：1985-05-24

申请人： VESTAR, INC.

发明人： Wing-Yiu Tin, George

IPC分类号： A61K9/50

CPC分类号： A61K9/127 ,  A61K51/1227 ,  A61K51/1234 ,  A61K2123/00

公开(公告)号：EP0127925A2

公开(公告)日：1984-12-12

申请号：EP84300854.1

申请日：1984-02-10

申请人： VESTAR, INC. ,  CITY OF HOPE NATIONAL MEDICAL CENTER

发明人： Gamble, Ronald Carl ,  Tin, George Wing-Yiu ,  Williams, Lawrence Ernest

IPC分类号： A61K49/02

CPC分类号： A61K9/1272 ,  A61K51/1203 ,  A61K51/1227 ,  A61K51/1234 ,  A61K2123/00

摘要： Leukocytes and other phagocytic cells are labelled by incubating the cells with labelled micellular particles. The label is preferably radioactive. The labelled material can be used for detecting the locus of an infection by administering to a subject leukocytes radiolabelled by incubation with labelled micellular particles followed by scanning the subject to detect the locus of radiation emitted by the particles.

摘要翻译： 通过将细胞与标记的胶束颗粒一起孵育来标记白细胞和其它吞噬细胞。 标签优选是放射性的。 标记的材料可以用于通过对经过标记的胶束颗粒进行放射性标记的受试者白细胞进行检测来检测感染的位置，随后扫描受试者以检测由颗粒发射的辐射的位置。

公开(公告)号：EP3046586A4

公开(公告)日：2017-05-17

申请号：EP14845308

申请日：2014-09-18

申请人： UNIV CALIFORNIA

发明人： XU TING ,  DUBE NIKHIL

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K31/337 ,  A61K31/436 ,  A61K31/704 ,  A61K47/42 ,  A61K49/00 ,  A61K51/12

CPC分类号： A61K47/42 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/1658 ,  A61K31/337 ,  A61K31/436 ,  A61K31/704 ,  A61K47/543 ,  A61K47/60 ,  A61K49/0082 ,  A61K51/1227

摘要： The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

摘要翻译： 本发明提供了含有疏水嵌段和含有螺旋肽和两个聚合物嵌段的头团的双聚合物脂质 - 肽缀合物。 缀合物可以自组装形成螺旋束亚基，其依次组装以提供用于药物载体和其它试剂的胶束纳米载体。 还公开了含有共轭物的颗粒和形成颗粒的方法。

公开(公告)号：EP3046586A1

公开(公告)日：2016-07-27

申请号：EP14845308.7

申请日：2014-09-18

申请人： The Regents of the University of California

发明人： XU, Ting ,  DUBE, Nikhil

IPC分类号： A61K47/42

CPC分类号： A61K47/42 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/1658 ,  A61K31/337 ,  A61K31/436 ,  A61K31/704 ,  A61K47/543 ,  A61K47/60 ,  A61K49/0082 ,  A61K51/1227

摘要： The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

公开(公告)号：EP2591801A1

公开(公告)日：2013-05-15

申请号：EP11009032.1

申请日：2011-11-14

申请人： Universitätsklinikum Hamburg-Eppendorf ,  Universität Hamburg ,  Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts -

发明人： Herkel, Johannes ,  Carambia, Antonella ,  Freund, Barbara ,  Heeren, Jörg ,  Nielsen, Peter ,  Bruns, Oliver ,  Lohse, Ansgar ,  Lüth, Stefan ,  Weller, Horst ,  Salmen, Sunhild

IPC分类号： A61K39/39 ,  A61K47/48 ,  A61K9/14 ,  A61K9/51 ,  A61K9/00 ,  A61K9/107 ,  A61K9/50

CPC分类号： A61K9/146 ,  A61K9/0019 ,  A61K9/1075 ,  A61K39/0008 ,  A61K39/39 ,  A61K47/6907 ,  A61K49/0067 ,  A61K49/1809 ,  A61K49/1857 ,  A61K51/1227 ,  A61K2039/55555 ,  C12N5/0637 ,  C12N2502/14

摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

摘要翻译： 本发明涉及纳米颗粒抗原的肝细胞，尤其是，肝窦内皮细胞（LSEC）和/或枯否氏细胞的靶向递送，并且用于体内产生调节性T细胞，特别是CD4 + CD25 + FOXP3的+调节 T细胞（Treg）。 本发明提供了药物组合物和用于治疗自身免疫疾病，变态反应或其他慢性炎性病症的预防和治疗方法，以及用于产生调节性T细胞的。 在本发明使用的纳米颗粒包含a）一种包含胶束两亲性聚合物的渲染所述纳米颗粒是水溶性的，和b）一种肽，其包含与所述胶束的外部相关联的至少一个T细胞表位。 胶束可能会或可能不会包括固态疏水核心。

公开(公告)号：EP2367851A1

公开(公告)日：2011-09-28

申请号：EP09828508.3

申请日：2009-11-26

申请人： National Research Council of Canada

发明人： ABULROB, Abednelnasser ,  STANIMIROVIC, Danica ,  IQBAL, Umar ,  NIEH, Muping ,  KATSARAS, John

IPC分类号： C07K17/02 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  C07K16/00 ,  C07K16/26 ,  C07K16/28 ,  G01N33/544

CPC分类号： A61K49/0032 ,  A61K49/0002 ,  A61K49/0084 ,  A61K49/1812 ,  A61K51/1227 ,  A61K51/1234 ,  B82Y5/00 ,  C07K16/00 ,  C07K16/3053 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  G01N33/586

摘要： A nanoconjugate is formed from a self-assembled unilamellar vesicle (ULV), at least one contrast agent which may be a MRI contrast agent, a radioisotope or a fluorophore, and at least one antibody, which may be an IgG or an antibody fragment such as a single-domain antibody. The nanoconjugate be targetted with the antibody to receptors specific to certain disease states, and thus be used in diagnostic and imaging methods using the properties o contrast agent.

公开(公告)号：EP2398503B1

公开(公告)日：2018-10-31

申请号：EP10741884.0

申请日：2010-02-16

申请人： University of Washington

发明人： HO, Rodney, J.Y. ,  HOEKMAN, John, D. ,  MARAVILLA, Ken

IPC分类号： A61K49/18 ,  A61K49/10 ,  A61K33/14 ,  A61K51/04 ,  A61K49/08

CPC分类号： A61K49/1824 ,  A61K49/085 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1881 ,  A61K51/0408 ,  A61K51/0497 ,  A61K51/1227 ,  B82Y5/00

摘要： Lipid nanoparticles expressing metal ions and methods for using the compositions for magnetic resonance imaging.

公开(公告)号：EP2783679A4

公开(公告)日：2015-08-26

申请号：EP12851387

申请日：2012-08-23

申请人： ORIGINAL BIOMEDICALS CO LTD

发明人： WANG CHAU HUI ,  CHEN CHIA HUNG ,  LIN JOHNSON ,  CHEN JING YI ,  LIAO WEI CHUAN

IPC分类号： A61K9/107 ,  A61K9/51 ,  A61K31/00 ,  A61K33/24 ,  A61K47/48 ,  A61K49/18 ,  A61K51/12 ,  A61P35/00

CPC分类号： A61K49/1809 ,  A61K9/1075 ,  A61K9/5115 ,  A61K9/5153 ,  A61K47/547 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6907 ,  A61K51/1227

摘要： This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.

公开(公告)号：EP2780036A1

公开(公告)日：2014-09-24

申请号：EP12790425.8

申请日：2012-11-14

申请人： Universitätsklinikum Hamburg-Eppendorf ,  Universität Hamburg ,  Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts -

发明人： FREUND, Barbara ,  HEEREN, Jörg ,  NIELSEN, Peter ,  CARAMBIA, Antonella ,  HERKEL, Johannes ,  BRUNS, Oliver ,  LOHSE, Ansgar ,  LÜTH, Stefan ,  WELLER, Horst ,  SALMEN, Sunhild

IPC分类号： A61K39/39 ,  A61K47/48 ,  A61K9/14 ,  A61K9/51 ,  A61K9/00 ,  A61K9/107 ,  A61K9/50

CPC分类号： A61K9/146 ,  A61K9/0019 ,  A61K9/1075 ,  A61K39/0008 ,  A61K39/39 ,  A61K47/6907 ,  A61K49/0067 ,  A61K49/1809 ,  A61K49/1857 ,  A61K51/1227 ,  A61K2039/55555 ,  C12N5/0637 ,  C12N2502/14

摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

摘要翻译： 本发明涉及纳米颗粒抗原的肝细胞，尤其是，肝窦内皮细胞（LSEC）和/或枯否氏细胞的靶向递送，并且用于体内产生调节性T细胞，特别是CD4 + CD25 + FOXP3的+调节 T细胞（Treg）。 本发明提供了药物组合物和用于治疗自身免疫疾病，变态反应或其他慢性炎性病症的预防和治疗方法，以及用于产生调节性T细胞的。 在本发明使用的纳米颗粒包含a）一种包含胶束两亲性聚合物的渲染所述纳米颗粒是水溶性的，和b）一种肽，其包含与所述胶束的外部相关联的至少一个T细胞表位。 胶束可能会或可能不会包括固态疏水核心。