公开(公告)号：EP2745850B1

公开(公告)日：2018-05-16

申请号：EP12832548.7

申请日：2012-09-12

申请人： Shimadzu Corporation ,  Kyoto University

发明人： TAKEUCHI, Eri ,  HARA, Isao ,  YAMAHARA, Ryo ,  OZEKI, Eiichi ,  KIMURA, Shunsaku ,  KURIHARA, Kensuke

IPC分类号： A61K51/00 ,  A61B1/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/08 ,  A61K31/765 ,  A61N5/10 ,  A61P35/00 ,  G01T1/161 ,  A61K49/00 ,  A61B6/12 ,  A61B6/00 ,  A61B18/14 ,  A61B18/18 ,  A61K51/06 ,  A61B5/08 ,  A61B5/06 ,  A61B18/02 ,  A61K51/12

CPC分类号： A61K51/1244 ,  A61B5/055 ,  A61B5/061 ,  A61B5/0813 ,  A61B6/037 ,  A61B6/12 ,  A61B6/4258 ,  A61B6/485 ,  A61B6/508 ,  A61B8/085 ,  A61B18/0218 ,  A61B18/1477 ,  A61B18/1815 ,  A61B2018/0293 ,  A61B2018/1869 ,  A61K49/0054 ,  A61K49/0086 ,  A61K51/06 ,  A61K51/12 ,  A61K51/1237 ,  A61K2123/00 ,  A61N5/10 ,  A61N2005/1011 ,  A61N2005/1021 ,  A61N2005/1052 ,  A61N2005/1098

摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a ²-ray emitting nuclide. The nanoparticle for internal radiation therapy.

公开(公告)号：EP2651447B1

公开(公告)日：2018-08-29

申请号：EP11804942.8

申请日：2011-12-14

申请人： Technical University of Denmark ,  Rigshospitalet

发明人： PETERSEN, Anncatrine Luisa ,  HENRIKSEN, Jonas Rosager ,  RASMUSSEN, Palle Hedengran ,  KJÆR, Andreas ,  ANDRESEN, Thomas Lars

IPC分类号： A61K47/28 ,  A61K47/44 ,  A61K51/12

CPC分类号： A61K51/1237 ,  A61K51/0408 ,  A61K51/0482 ,  A61K51/12 ,  A61K51/1203 ,  A61K51/1234

摘要： The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

公开(公告)号：EP2161020A1

公开(公告)日：2010-03-10

申请号：EP08163933.8

申请日：2008-09-09

申请人： Koninklijke Philips Electronics N.V.

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K9/51 ,  A61K47/48 ,  A61K49/00

CPC分类号： C08G81/025 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5146 ,  A61K49/0414 ,  A61K49/126 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1818 ,  A61K51/06 ,  A61K51/065 ,  A61K51/1217 ,  A61K51/1237 ,  A61K51/1251

摘要： Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

摘要翻译： 描述的是具有螯合部分的两亲性聚合物。 两亲聚合物是包含亲水嵌段和疏水嵌段的嵌段共聚物，螯合部分连接到亲水嵌段的端基。 所公开的聚合物能够自组装成结构如胶束和聚合物囊泡。 使用与螯合部分配位络合物形式的合适金属，本发明的螯合两亲性聚合物适用于需要金属标记的各种成像技术，例如MRI（T 1 / T 2加权造影剂或CEST造影剂 ）SPECT，PET或光谱CT。

公开(公告)号：EP1928313A1

公开(公告)日：2008-06-11

申请号：EP06815868.2

申请日：2006-09-28

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： THERIEN, Michael, J. ,  HAMMER, Daniel, A. ,  GHOROGHCHIAN, Paiman, Peter ,  LI, Guizhi

IPC分类号： A61B5/055

CPC分类号： A61K9/1273 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/34 ,  A61K48/00 ,  A61K49/1812 ,  A61K51/1237 ,  C08G63/664 ,  C08L71/02

摘要： The invention concerns a block copolymer of polyethylene oxide and polycaprolactone, the polyethylene oxide having a number average molecular weight from about 2.0 to about 3.8 kD, the block copolymer having a fraction of polyethylene oxide of from about 11.8 to 18.8 percent by weight. The invention also concerns polymersomes made from such copolymers and to methods of making the polymersomes.

公开(公告)号：EP3011977A1

公开(公告)日：2016-04-27

申请号：EP14191188.3

申请日：2014-10-30

申请人： Institute of Nuclear Energy Research Atomic Energy Council

发明人： Chiu, Shu-Pei ,  Lin, Bo-Sian ,  Lin, Liang-Ting ,  Lee, Yi-Jang ,  Lee, Te-Wei ,  Huang, Feng-Yun ,  Lo, Jen-Mau

IPC分类号： A61K51/12 ,  A61P35/00 ,  A61P35/04 ,  A61K103/10

CPC分类号： A61K51/065 ,  A61J1/05 ,  A61K51/1234 ,  A61K51/1237

摘要： The invention relates to a kit for preparation of target radiopharmaceuticals, a method of using the kit to prepare target radiopharmaceuticals and use of the target radiopharmaceuticals. The target radiopharmaceuticals comprise a radio-nuclear loading on liposome and inhibit the tumor growth and metastatic progression of head and neck cancer, lung cancer and brain cancer. The radiopharmaceuticals may be used for treating the mentioned cancers.

摘要翻译： 本发明涉及用于制备靶放射性药物的试剂盒，使用该试剂盒制备靶放射性药物的方法和靶放射性药物的使用。 靶向放射性药物包括在脂质体上的放射性核载荷并抑制头颈癌，肺癌和脑癌的肿瘤生长和转移进展。 放射性药物可用于治疗所述癌症。

公开(公告)号：EP1879626A2

公开(公告)日：2008-01-23

申请号：EP06750510.7

申请日：2006-04-17

申请人： Massachusetts Institute of Technology

发明人： COLTON, Clark K. ,  WATTERSON, Arthur ,  KUMAR, Rajesh ,  PARMAR, Virinder S. ,  FISHER, Robert ,  KUMAR, Jayant

IPC分类号： A61K51/00 ,  A61K38/19 ,  A61K38/22 ,  C08G63/91

CPC分类号： A61K49/126 ,  A61K9/51 ,  A61K31/785 ,  A61K38/10 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6907 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61K49/14 ,  A61K49/1809 ,  A61K49/1818 ,  A61K51/06 ,  A61K51/1237 ,  B82Y5/00 ,  C08G63/668 ,  C08G63/672 ,  C08G63/6826 ,  C08G63/6854 ,  C08G63/914 ,  C08G69/40 ,  C08G73/028 ,  C08G2261/126 ,  C08L77/00 ,  C08L79/02 ,  G01N33/5091 ,  G01N33/57492

摘要： The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drags, or a combination thereof for diagnostic and therapeutic purposes.

公开(公告)号：EP1330268A1

公开(公告)日：2003-07-30

申请号：EP01979715.8

申请日：2001-10-11

申请人： Targesome, Inc.

发明人： LI, King, Chuen ,  BEDNARSKI, Mark, David ,  WARTCHOW, Charles, Aaron ,  PEASE, John, S. ,  DECHENE, Neal, Edward ,  TRULSON, Julie ,  SHEN, Zhi, Min

IPC分类号： A61K51/00

CPC分类号： A61K49/0002 ,  A61K49/16 ,  A61K49/1812 ,  A61K51/1045 ,  A61K51/1237

摘要： Therapeutic and imaging agents which are comprised of a targeting entity, a therapeutic or treatment entity and a linking carrier are provided. The linking carrier imparts additional advantages to the therapeutic agents, which are not provided by conventional linking methods. Preferred agents of the present invention comprises a lipid construct, vesicle, liposome, or polymerized liposome. In some cases, the therapeutic or treatment entity is a radioisotope, chemotherapeutic agent, prodrug, toxin, or gene encoding a protein that exhibits cell toxicity. Preferably, the agent is further comprised of a stabilizing entity that imparts additional advantages to the therapeutic or imaging agent.

公开(公告)号：EP2323636B1

公开(公告)日：2015-08-12

申请号：EP09787135.4

申请日：2009-09-08

申请人： Koninklijke Philips N.V.

发明人： GRUELL, Holger ,  DE VRIES, Anke ,  LANGEREIS, Sander ,  LUB, Johan ,  AUSSEMS-CUSTERS, Erica, M., G.

IPC分类号： A61K9/51 ,  A61K47/48 ,  A61K49/00

CPC分类号： C08G81/025 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5146 ,  A61K49/0414 ,  A61K49/126 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1818 ,  A61K51/06 ,  A61K51/065 ,  A61K51/1217 ,  A61K51/1237 ,  A61K51/1251

摘要： Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

公开(公告)号：EP2745850A1

公开(公告)日：2014-06-25

申请号：EP12832548.7

申请日：2012-09-12

申请人： Shimadzu Corporation ,  Kyoto University

发明人： TAKEUCHI, Eri ,  HARA, Isao ,  YAMAHARA, Ryo ,  OZEKI, Eiichi ,  KIMURA, Shunsaku ,  KURIHARA, Kensuke

IPC分类号： A61K51/00 ,  A61B1/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/08 ,  A61K31/765 ,  A61N5/10 ,  A61P35/00 ,  G01T1/161

CPC分类号： A61K51/1244 ,  A61B5/055 ,  A61B5/061 ,  A61B5/0813 ,  A61B6/037 ,  A61B6/12 ,  A61B6/4258 ,  A61B6/485 ,  A61B6/508 ,  A61B8/085 ,  A61B18/0218 ,  A61B18/1477 ,  A61B18/1815 ,  A61B2018/0293 ,  A61B2018/1869 ,  A61K49/0054 ,  A61K49/0086 ,  A61K51/06 ,  A61K51/12 ,  A61K51/1237 ,  A61K2123/00 ,  A61N5/10 ,  A61N2005/1011 ,  A61N2005/1021 ,  A61N2005/1052 ,  A61N2005/1098

摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a β-ray emitting nuclide. The nanoparticle for internal radiation therapy.

摘要翻译： 本发明提供广泛适用于一般实体癌症的治疗系统，可以实现癌症治疗的副作用降低和癌症复发和转移的抑制，并且不需要昂贵的药物如抗体; 和用于内部放射治疗的纳米颗粒。 一种用于血管损伤部位的内部放射治疗的系统，包括：装置，其包括用于获取显示血管病变部位的位置的图像数据的装置，以及用于定位应该穿刺到血管损伤部位的针的装置， 基于图像数据的血管病变部位; 以及包含两亲性嵌段聚合物的纳米颗粒，所述两亲性嵌段聚合物包含具有肌氨酸单元的亲水性嵌段和具有乳酸单元的疏水性嵌段，以及用2号放射性核素标记的物质。 用于内部放射治疗的纳米颗粒。

公开(公告)号：EP1928313A4

公开(公告)日：2012-03-21

申请号：EP06815868

申请日：2006-09-28

申请人： UNIV PENNSYLVANIA

发明人： THERIEN MICHAEL J ,  HAMMER DANIEL A ,  GHOROGHCHIAN PAIMAN PETER ,  LI GUIZHI

IPC分类号： A61K47/48 ,  A61K9/127 ,  A61K47/34 ,  A61K51/12

CPC分类号： A61K9/1273 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/34 ,  A61K48/00 ,  A61K49/1812 ,  A61K51/1237 ,  C08G63/664 ,  C08L71/02