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公开(公告)号:EP1841420B1
公开(公告)日:2011-12-07
申请号:EP06717284.1
申请日:2006-01-04
IPC分类号: A01N41/10 , A01N43/06 , A01N43/08 , A61K31/10 , A61K31/34 , A61K31/38 , C07C315/00 , C07C317/00
CPC分类号: A61K31/337
摘要: α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
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公开(公告)号:EP1841420A2
公开(公告)日:2007-10-10
申请号:EP06717284.1
申请日:2006-01-04
IPC分类号: A61K31/337
CPC分类号: A61K31/337
摘要: α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
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3.USE OF ALPHA, BETA UNSATURATED ARYL SULFONES FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY 有权
标题翻译: ALPHA,BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE公开(公告)号:EP1370253B8
公开(公告)日:2008-11-26
申请号:EP02733811.0
申请日:2002-02-28
申请人: Temple University - of the Commonwealth System of Higher Education , Onconova Therapeutics, Inc
IPC分类号: A61K31/10 , A61K31/277 , A61K31/4409 , A61K31/426 , A61K31/40 , A61P39/00
CPC分类号: A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
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4.USE OF ALPHA, BETA UNSATURATED ARYL SULFONES FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY 有权
标题翻译: ALPHA,BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE公开(公告)号:EP1370253B1
公开(公告)日:2008-09-03
申请号:EP02733811.0
申请日:2002-02-28
IPC分类号: A61K31/10 , A61K31/277 , A61K31/4409 , A61K31/426 , A61K31/40 , A61P39/00
CPC分类号: A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
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5.UNSATURATED ARYL SULFONES FOR PROTECTING NORMAL CELLS FROM CYTOTOXICITY OF CHEMOTHERAPEUTIC AGENTS 有权
标题翻译: 不饱和芳基砜对于正常细胞对细胞毒性作用化疗药物的保护公开(公告)号:EP1223923B1
公开(公告)日:2010-03-31
申请号:EP00973486.4
申请日:2000-10-11
IPC分类号: A61K31/10 , A61K31/12 , A61K31/192 , A61K45/06 , C07C317/10 , A61P35/00
CPC分类号: A61K45/06 , A61K31/10 , A61K31/12 , A61K31/192 , C07C317/10 , C07C317/14 , C07C317/18 , C07C317/44 , C07C2603/24 , A61K2300/00
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