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1.发明授权USE OF ALPHA, BETA UNSATURATED ARYL SULFONES FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY 有权ALPHA，BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE
公开(公告)号：EP1370253B8
公开(公告)日：2008-11-26
申请号：EP02733811.0
申请日：2002-02-28
申请人： Temple University - of the Commonwealth System of Higher Education , Onconova Therapeutics, Inc
IPC分类号： A61K31/10 , A61K31/277 , A61K31/4409 , A61K31/426 , A61K31/40 , A61P39/00
CPC分类号： A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
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2.发明授权USE OF ALPHA, BETA UNSATURATED ARYL SULFONES FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY 有权ALPHA，BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE
公开(公告)号：EP1370253B1
公开(公告)日：2008-09-03
申请号：EP02733811.0
申请日：2002-02-28
IPC分类号： A61K31/10 , A61K31/277 , A61K31/4409 , A61K31/426 , A61K31/40 , A61P39/00
CPC分类号： A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
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公开(公告)号：EP1841420B1
公开(公告)日：2011-12-07
申请号：EP06717284.1
申请日：2006-01-04
IPC分类号： A01N41/10 , A01N43/06 , A01N43/08 , A61K31/10 , A61K31/34 , A61K31/38 , C07C315/00 , C07C317/00
CPC分类号： A61K31/337
摘要： α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
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公开(公告)号：EP1841420A2
公开(公告)日：2007-10-10
申请号：EP06717284.1
申请日：2006-01-04
IPC分类号： A61K31/337
CPC分类号： A61K31/337
摘要： α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
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5.发明授权UNSATURATED ARYL SULFONES FOR PROTECTING NORMAL CELLS FROM CYTOTOXICITY OF CHEMOTHERAPEUTIC AGENTS 有权不饱和芳基砜对于正常细胞对细胞毒性作用化疗药物的保护
公开(公告)号：EP1223923B1
公开(公告)日：2010-03-31
申请号：EP00973486.4
申请日：2000-10-11
IPC分类号： A61K31/10 , A61K31/12 , A61K31/192 , A61K45/06 , C07C317/10 , A61P35/00
CPC分类号： A61K45/06 , A61K31/10 , A61K31/12 , A61K31/192 , C07C317/10 , C07C317/14 , C07C317/18 , C07C317/44 , C07C2603/24 , A61K2300/00
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6.发明公开METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH $g(a), $g(b) UNSATURATED ARYL SULFONES 有权ALPHA，BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE
公开(公告)号：EP1370253A2
公开(公告)日：2003-12-17
申请号：EP02733811.0
申请日：2002-02-28
IPC分类号： A61K31/10 , A61K31/275 , A61K31/435 , A61K31/425 , A61K31/40 , A61K31/35
CPC分类号： A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
摘要： Pre-treatment with α, β unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective α, β unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the α, β unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of α, β unsatured arylsulfone.
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