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    DRUG COATING LAYER
    6.
    发明公开
    DRUG COATING LAYER 审中-公开

    公开(公告)号：EP3441093A1

    公开(公告)日：2019-02-13

    申请号：EP18178130.3

    申请日：2014-04-01

    Applicant: Terumo Kabushiki Kaisha

    Inventor： YAMASHITA, Keiko ,  GOTOU, Hiroshi ,  NOZAWA, Shigenori ,  MORIMOTO, Katsumi ,  KASUKAWA, Hiroaki

    IPC: A61L31/00 ,  A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

    Abstract: [Problem] The present invention is to provide a drug coating layer which has low toxicity and a high intravascular stenosis inhibitory effect, when delivering medical device coated with a drug into the body and medical device using the same. The drug coating layer is a drug coating layer having a morphological form including a plurality of elongate bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongate bodies are nearly linear in shape, and the long axes of the elongate bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongate body intersects.

    LIPOSOME COMPOSITION AND PROCESS FOR PRODUCTION THEREOF
    7.
    发明公开
    LIPOSOME COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 有权
    脂质体及其制造方法

    公开(公告)号：EP2630953A1

    公开(公告)日：2013-08-28

    申请号：EP11854287.7

    申请日：2011-12-27

    Applicant: Terumo Kabushiki Kaisha

    Inventor： YAMASHITA, Keiko ,  NOZAWA, Shigenori

    IPC: A61K9/127 ,  A61K47/24 ,  A61K47/34 ,  B01J13/02

    CPC classification number: A61K9/0002 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  B01J13/02

    Abstract: The purpose of the present invention is to provide a liposome composition into which a drug can be introduced in a high encapsulation amount, which has sustained release properties to such an extent that a effective concentration can be maintained at a clinically satisfactory level, and which is suitable for subcutaneous administration or the like. This liposome composition includes: a first liposome which has an outer membrane composed of a multilayered lipid bilayer; and a plurality of second liposomes which are accommodated in a first liposome inner region defined by the outer membrane and each of which has an outer membrane composed of a multilayered lipid bilayer. The liposome composition has second liposome inner regions each defined by the outer membrane of each of the second liposomes. An ion gradient is formed at least between each of the second liposome inner regions and the outside of the first liposome.

    LONG-LASTING CONTROLLED-RELEASE LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME
    10.
    发明授权
    LONG-LASTING CONTROLLED-RELEASE LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME 有权
    根据上述制造延边控释和过程脂质体

    公开(公告)号：EP2656835B1

    公开(公告)日：2016-06-29

    申请号：EP12763544.9

    申请日：2012-03-22

    Applicant: Terumo Kabushiki Kaisha

    Inventor： YAMASHITA, Keiko ,  NOZAWA, Shigenori ,  OTOMO, Naoki

    IPC: A61K9/127 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61K31/445 ,  A61K31/27 ,  A61K31/407 ,  A61K31/519 ,  A61K31/55

    CPC classification number: A61K9/1277 ,  A61K9/127 ,  A61K9/1278 ,  A61K31/27 ,  A61K31/407 ,  A61K31/445 ,  A61K31/519 ,  A61K31/55

    Abstract: The invention provides a liposome composition, which is obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained in a total concentration of 100 to 200 w/v% in a water-miscible organic solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution, thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v%, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution, wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane, including the first aqueous phase solution, and an aqueous phase in an external region of the liposome membrane, including the second aqueous phase solution, and a drug can be introduced in a high encapsulation amount. The invention also provides a liposome preparation which has long-lasting controlled-release properties while maintaining a clinically sufficient effective concentration and is suitable for subcutaneous administration and so on.

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