公开(公告)号：EP3290035B1

公开(公告)日：2019-05-15

申请号：EP17180400.8

申请日：2013-03-06

申请人： The Board of Trustees of the University of Illinois ,  Vanquish Oncology, Inc. ,  The Johns Hopkins University

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark J. ,  HANDLEY, Michael K. ,  JOSHI, Avadhut ,  RIGGINS, Gregory J. ,  TARASOW, Theodore M.

IPC分类号： A61K31/495 ,  A61K31/53 ,  A61P35/00 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10

公开(公告)号：EP3290035A1

公开(公告)日：2018-03-07

申请号：EP17180400.8

申请日：2013-03-06

申请人： The Board of Trustees of the University of Illinois ,  Vanquish Oncology, Inc. ,  The Johns Hopkins University

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark J. ,  HANDLEY, Michael K. ,  JOSHI, Avadhut ,  RIGGINS, Gregory J. ,  TARASOW, Theodore M.

IPC分类号： A61K31/495 ,  A61K31/4188 ,  A61P35/00 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10

CPC分类号： A61K31/495 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4188 ,  A61K31/53 ,  A61K47/10 ,  A61K2300/00

摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

公开(公告)号：EP2822546B1

公开(公告)日：2017-07-12

申请号：EP13758061.9

申请日：2013-03-06

申请人： The Board of Trustees of the University of Illinois ,  Vanquish Oncology, Inc. ,  The Johns Hopkins University

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark J. ,  HANDLEY, Michael K. ,  JOSHI, Avadhut ,  RIGGINS, Gregory J. ,  TARASOW, Theodore M.

IPC分类号： A61K31/495 ,  A61K31/4188 ,  A61P35/00 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10

CPC分类号： A61K31/495 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4188 ,  A61K47/10 ,  A61K2300/00

公开(公告)号：EP2822546A1

公开(公告)日：2015-01-14

申请号：EP13758061.9

申请日：2013-03-06

申请人： The Board of Trustees of the University of Illinois ,  Vanquish Oncology, Inc. ,  The Johns Hopkins University

发明人： HERGENROTHER, Paul J. ,  BOTHAM, Rachel C. ,  FAN, Timothy M. ,  GILBERT, Mark J. ,  HANDLEY, Michael K. ,  JOSHI, Avadhut ,  RIGGINS, Gregory J. ,  TARASOW, Theodore M.

IPC分类号： A61K31/05 ,  A61K31/175 ,  A61K31/4172 ,  A61K31/4192 ,  A61K31/495 ,  A61P35/00

CPC分类号： A61K31/495 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4188 ,  A61K47/10 ,  A61K2300/00

摘要： The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

摘要翻译： 本发明提供了诱导细胞死亡的组合物和方法，例如癌细胞死亡。 公开了化合物和相关使用方法的组合，包括在治疗中使用化合物治疗癌症和选择性诱导细胞凋亡。 所公开的药物组合可以具有比其它化合物和化合物组合更低的神经毒性作用。

公开(公告)号：EP3253384A2

公开(公告)日：2017-12-13

申请号：EP16747414.7

申请日：2016-02-08

申请人： The Johns Hopkins University

发明人： BAI, Ren-yuan ,  STAEDTKE, Verena ,  JOSHI, Avadhut D. ,  RIGGINS, Gregory J.

IPC分类号： A61K31/4184 ,  A61K9/16 ,  A61K9/28 ,  A61P35/00

CPC分类号： A61K31/4184 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/1605 ,  A61K9/50 ,  A61K31/192 ,  A61K31/473 ,  A61K45/06 ,  G01N21/35

摘要： Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent.

公开(公告)号：EP2326735B1

公开(公告)日：2016-11-16

申请号：EP09792198.5

申请日：2009-09-03

申请人： The Johns Hopkins University ,  Duke University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth W. ,  PARSONS, D. Williams ,  ZHANG, Xiaosong ,  LIN, Jimmy Cheng-Ho ,  LEARY, Rebecca J. ,  ANGENENDT, Philipp ,  PAPADOPOULOS, Nickolas ,  VELCULESCU, Victor ,  PARMIGIANI, Giovanni ,  KARCHIN, Rachel ,  JONES, Sian ,  YAN, Hai ,  BIGNER, Darell ,  KUAN, Chien-Tsun ,  RIGGINS, Gregory J.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156