公开(公告)号：EP2961849A2

公开(公告)日：2016-01-06

申请号：EP14715725.9

申请日：2014-02-27

申请人： The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： REGEV, Aviv ,  KUCHROO, Vijay ,  PARK, Hongkun ,  YOSEF, Nir ,  SHALEK, Alexander, K. ,  GAUBLOMME, Jellert ,  JOLLER, Nicole C. ,  WU, Chuan ,  ANDERSON, Ana, Carrizosa

IPC分类号： C12Q1/68 ,  A61K39/39 ,  C12N5/0783

CPC分类号： C12N5/0636 ,  A61K31/12 ,  A61K31/198 ,  A61K31/37 ,  A61K31/4745 ,  A61K31/66 ,  A61K31/661 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/739 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K38/1767 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/363 ,  A61K38/4866 ,  A61K48/00 ,  C07K16/28 ,  C07K2317/76 ,  C12N5/0637 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2323 ,  C12N2501/25 ,  C12N2501/90 ,  C12Q1/6881 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y304/21069 ,  G01N33/56972 ,  G01N2570/00 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP3368689A2

公开(公告)日：2018-09-05

申请号：EP16795490.8

申请日：2016-10-28

申请人： The Broad Institute Inc. ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Regev, Aviv ,  Anderson, Ana C. ,  Cong, Le ,  Kuchroo, Vijay K. ,  Singer, Meromit ,  Wang, Chao

发明人： REGEV, Aviv ,  ANDERSON, Ana, Carrizosa ,  CONG, Le ,  KUCHROO, Vijay, K. ,  SINGER, Meromit ,  WANG, Chao

IPC分类号： C12Q1/68 ,  C12N5/0783

CPC分类号： C12Q1/6886 ,  C12N5/0636 ,  C12N2510/00 ,  C12Q1/6881 ,  C12Q2600/158

摘要： The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.

公开(公告)号：EP3638218A1

公开(公告)日：2020-04-22

申请号：EP18818420.4

申请日：2018-06-14

申请人： The Broad Institute, Inc. ,  Massachusetts Institute Of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： REGEV, Aviv ,  ANDERSON, Ana, Carrizosa ,  SUBRAMANIAN, Ayshwarya ,  ROZENBLATT-ROSEN, Orit

IPC分类号： A61K31/00 ,  C07K14/705 ,  C07K16/24 ,  C07K16/28 ,  C12Q1/68 ,  G06F19/00