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    DEVICE AND METHOD FOR CULTURING CELLS IN A BIOMIMETIC ENVIRONMENT
    3.
    发明授权
    DEVICE AND METHOD FOR CULTURING CELLS IN A BIOMIMETIC ENVIRONMENT 有权
    用于在生物圈环境中培养细胞的装置和方法

    公开(公告)号：EP2721141B1

    公开(公告)日：2018-02-07

    申请号：EP12732900.1

    申请日：2012-06-15

    申请人： The Charles Stark Draper Laboratory, Inc.

    发明人： CHAREST, Joseph L. ,  FROHLICH, Else ,  BORENSTEIN, Jeffrey T.

    IPC分类号： C12M3/00

    CPC分类号： C12M23/16 ,  C12M25/00 ,  C12M41/00

    摘要： Devices and methods are disclosed herein for a biomimetic flow apparatus. The biomimetic flow apparatus includes a microfluidic flow channel and an inlet in fluid connection with the flow channel for allowing fluid to flow into the flow channel. The flow channel has at least one surface with a topography formed therein. The topography of the at least one surface of the flow channel is selected to cause cells in a cell layer above the surface to achieve an arrangement, behavior, or morphology. The cell arrangement, behavior, or morphology is determined at least in part by the topography of the at least one surface.

    SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE
    9.
    发明公开
    SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE 有权
    用于增加微流体装置中未除尘颗粒的对流清除的系统和方法

    公开(公告)号：EP3191223A1

    公开(公告)日：2017-07-19

    申请号：EP15759586.9

    申请日：2015-08-21

    申请人： The Charles Stark Draper Laboratory, Inc. ,  Johnson & Johnson Innovation LLC

    发明人： CHAREST, Joseph L. ,  NOHILLY, Martin ,  DIBIASIO, Christopher ,  BORENSTEIN, Jeffrey T. ,  LAURENZI, Mark ,  WILSON, Jonathan

    IPC分类号： B01L3/00 ,  A61M1/16 ,  A61M1/34 ,  B01D61/18

    CPC分类号： A61M1/34 ,  A61M1/1631 ,  A61M1/3403 ,  A61M1/341 ,  A61M2205/0244 ,  A61M2205/3331 ,  B01D61/24 ,  B01D63/082 ,  B01D2311/14 ,  B01D2319/06

    摘要： A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets.

    摘要翻译： 提供了用于增加流体中颗粒的对流清除的微流体装置。 在本文描述的一些实现中，微流体装置包括多个层，每个层限定注入物，血液和滤液通道。 每个通道都有一个压力曲线。 该装置还可以包括一个或多个压力控制特征。 压力控制功能控制沿装置长度的压力分布之间的差异。 例如，压力控制特征可以控制滤液通道的压力分布与血液通道的压力分布之间的差异。 在一些实施方式中，压力控制特征控制两个通道之间的压力差，使得差异沿通道的长度变化小于通道入口处的通道之间的压力差的50％。