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公开(公告)号：EP3474852A1
公开(公告)日：2019-05-01
申请号：EP17737130.9
申请日：2017-06-23
申请人： The Charles Stark Draper Laboratory, Inc. , Massachusetts Eye & Ear Infirmary , Massachusetts Institute of Technology
发明人： BORENSTEIN, Jeffrey T. , PARARAS, Erin , KIM, Ernest S. , TANDON, Vishal , AYOOB, Andrew , MCKENNA, Michael , SEWELL, William , PEPPI, Marcello , WEINBERG, Marc , LANGER, Robert
IPC分类号： A61K31/498 , A61K47/10 , A61K9/00 , A61P27/16
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公开(公告)号：EP2214590B1
公开(公告)日：2016-08-31
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
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公开(公告)号：EP2214590A1
公开(公告)日：2010-08-11
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
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公开(公告)号：EP3766516A1
公开(公告)日：2021-01-20
申请号：EP19201980.0
申请日：2014-03-14
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
发明人： STARY, Georg , RADOVIC-MORENO, Aleksandar Filip , BASTO, Pamela A. , STARNBACH, Michael N. , LANGER, Robert , FAROKHZAD, Omid C. , ANDRIAN, Ulrich Von
IPC分类号： A61K39/118 , A61K45/00 , A01N63/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P33/00 , A61P37/04
摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.
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公开(公告)号：EP2344186B1
公开(公告)日：2017-04-05
申请号：EP09740580.7
申请日：2009-10-09
申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc.
发明人： IANNACONE, Matteo , ALEXIS, Frank , BASTO, Pamela , MOSEMAN, Ashley , SHI, Jinjun , LANGER, Robert , FAROKHZAD, Omid, C. , VON ANDRIAN, Ulrich , TONTI, Elena
CPC分类号： A61K39/00 , A61K39/0002 , A61K39/0013 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/20234
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公开(公告)号：EP2968510A1
公开(公告)日：2016-01-20
申请号：EP14770692.3
申请日：2014-03-14
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
发明人： STARY, Georg , RADOVIC-MORENO, Aleksandar, Filip , BASTO, Pamela, A. , STARNBACH, Michael, N. , LANGER, Robert , FAROKHZAD, Omid, C. , ANDRIAN, Ulrich, Von
IPC分类号： A61K39/118 , A61K45/00 , A01N63/00
CPC分类号： A61K39/118 , A61K31/4745 , A61K31/711 , A61K39/0208 , A61K39/04 , A61K39/085 , A61K39/092 , A61K45/06 , A61K2039/521 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55572 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/16034 , C12N2770/20034 , Y02A50/386 , Y02A50/388 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.
摘要翻译： 本文提供了包含灭活的病原体和一种或多种辅助剂负载的聚合物纳米粒子的新组合物，其中负载佐剂的纳米粒子与灭活的病原体结合。 这些组合物可用于预防和/或治疗由特定病原体引起的疾病，尤其是当施用于受试者的粘膜时。
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7.发明公开TARGETING OF ANTIGEN PRESENTING CELLS WITH IMMUNONANOTHERAPEUTICS 有权ZIENEN VON ANTIGENPRÄSENTIERENDENZELLEN MIT IMMUNONANOTHERAPEUTIKA
公开(公告)号：EP2344187A1
公开(公告)日：2011-07-20
申请号：EP09740582.3
申请日：2009-10-09
申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc.
发明人： SHI, Jinjun , ALEXIS, Frank , IANNACONE, Matteo , MOSEMAN, Ashley , BASTO, Pamela , LANGER, Robert , FAROKHZAD, Omid, C. , VON ANDRIAN, Ulrich , TONTI, Elena
IPC分类号： A61K39/00
CPC分类号： A61K47/48869 , A61K39/00 , A61K47/6925 , A61K47/6935
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号：EP1730286A2
公开(公告)日：2006-12-13
申请号：EP05724526.8
申请日：2005-03-04
CPC分类号： C12N15/88 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2800/30 , C12N2830/008 , C12N2830/15
摘要： Aspects of the invention relate to nucleic acids molecules that are useful for specifically destroying selected cells, tissues, or organs. Aspects of the invention are useful for treating diseases (e.g., cancer) that affect cells, tissues, or organs.
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公开(公告)号：EP1476255A2
公开(公告)日：2004-11-17
申请号：EP02750237.6
申请日：2002-07-23
发明人： LAHANN, Jörg , LANGER, Robert , JENSEN, Klavs, F.
IPC分类号： B05D7/24
CPC分类号： B82Y30/00 , B05D1/60 , B82Y10/00 , C23C16/00 , Y10T428/3154 , Y10T428/31855
摘要： A method for coating of variable substrates with highly reactive polymers. Its combination with microcontact printing is used for generating several devices such as patterned arrays of ligands for high throughput screening.
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公开(公告)号：EP3470089A1
公开(公告)日：2019-04-17
申请号：EP18199415.3
申请日：2014-12-12
摘要： The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery particle formulations and/or systems comprising one or more components of a CRISPR-Cas system, which are means for targeting sites for delivery. The delivery particle formulations of the invention are preferably nanoparticle delivery formulations and/or systems. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
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