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公开(公告)号：EP4021480A1
公开(公告)日：2022-07-06
申请号：EP20858147.0
申请日：2020-08-28
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公开(公告)号：EP3514229A1
公开(公告)日：2019-07-24
申请号：EP19155870.9
申请日：2009-05-26
发明人： KADOURI, Avinoam , BAR-ILAN, Avihay , MELAMED, Eldad , OFFEN, Daniel , SADAN, Ofer , BAHAT-STROMZA, Merav
IPC分类号： C12N5/079 , C12N5/0775 , A61K35/28 , A61P25/28
摘要： The present invention relates to an isolated human cell comprising a cell being non-genetically manipulated, and characterized by: a) expressing tyrosine hydroxylase, nestin and H-NF and b) secreting brain-derived neurotrophic factor (BDNF), and b) not secreting nerve growth factor (NGF) wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of said BDNF in a mesenchymal stem cell.
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公开(公告)号：EP2478009A1
公开(公告)日：2012-07-25
申请号：EP10768079.5
申请日：2010-09-16
发明人： OFFEN, Daniel , LEV, Nirit , MELAMED, Eldad
CPC分类号： C07K14/4702 , A61K38/00
摘要： Isolated DJ-1 related peptides are disclosed and pharmaceutical compositions comprising same for treating oxidative stress-related disorders.
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4.发明公开
公开(公告)号：EP3600449A1
公开(公告)日：2020-02-05
申请号：EP18778299.0
申请日：2018-03-29
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公开(公告)号：EP3496730A1
公开(公告)日：2019-06-19
申请号：EP17841210.2
申请日：2017-08-14
发明人： OFFEN, Daniel , PERETS, Nisim
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公开(公告)号：EP2285951B1
公开(公告)日：2018-07-04
申请号：EP09754337.5
申请日：2009-05-26
发明人： KADOURI, Avinoam , BAR-ILAN, Avihay , MELAMED, Eldad , OFFEN, Daniel , SADAN, Ofer , BAHAT-STROMZA, Merav
CPC分类号： A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
摘要： The present invention relates to an isolated human cell comprising a cell being non-genetically manipulated, and characterized by: a) expressing tyrosine hydroxylase, nestin and H-NF and b) secreting brain-derived neurotrophic factor (BDNF), and b) not secreting nerve growth factor (NGF) wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of said BDNF in a mesenchymal stem cell.
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7.发明公开STEM CELL-DERIVED NEURAL CELLS FOR CELL THERAPY IN NEUROLOGICAL DISORDERS 审中-公开从得到神经细胞，以神经系统疾病细胞治疗干细胞
公开(公告)号：EP2782587A1
公开(公告)日：2014-10-01
申请号：EP12852394.1
申请日：2012-11-21
发明人： PITARU, Sandu , GANZ, Javier , OFFEN, Daniel , MELAMED, Eldad
IPC分类号： A61K35/12 , A61K48/00 , C12N5/0797
CPC分类号： A61K35/30 , A61K2035/124 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/41 , C12N2501/415 , C12N2501/999 , C12N2506/097
摘要： The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
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8.发明授权ISOLATED CELLS AND POPULATIONS COMPRISING SAME FOR THE TREATMENT OF CNS DISEASES 有权分离出的细胞种群含中枢神经系统疾病的治疗
公开(公告)号：EP1893747B1
公开(公告)日：2014-09-03
申请号：EP06766101.7
申请日：2006-06-18
IPC分类号： C12N5/0775 , C12N5/079
CPC分类号： C12N5/0669 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/40 , C12N2506/1353
摘要： An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
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9.发明公开
公开(公告)号：EP2680864A1
公开(公告)日：2014-01-08
申请号：EP12711003.9
申请日：2012-03-01
CPC分类号： A61K35/34 , A61K35/12 , A61K38/00 , A61K38/185 , A61K38/1866 , A61K38/30 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/13 , C12N2501/165 , C12N2510/00
摘要： An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
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公开(公告)号：EP4405322A1
公开(公告)日：2024-07-31
申请号：EP22872345.8
申请日：2022-09-22
发明人： OFFEN, Daniel , YOM-TOV, Nataly
IPC分类号： C07C33/025 , A61K31/352 , A61K9/14 , A61K47/54
CPC分类号： A61K47/544 , A61K31/685
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