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公开(公告)号：EP2663328A1
公开(公告)日：2013-11-20
申请号：EP12734409.1
申请日：2012-01-10
申请人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services , Royal Cornwall Hospital Trust
发明人： EMERSON, Suzanne U. , SHUKLA, Priyanka , NGUYEN, Hanh T. , PURCELL, Robert H. , DALTON, Harry R. , BENDALL, Richard P.
IPC分类号： A61K39/29
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/47 , C12N15/86 , C12N2770/28121 , C12N2770/28122 , C12N2770/28134 , C12N2770/28143 , C12N2770/28151 , C12N2770/28152 , C12Q1/707
摘要： The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
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公开(公告)号：EP2663328B1
公开(公告)日：2018-09-19
申请号：EP12734409.1
申请日：2012-01-10
申请人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services , Royal Cornwall Hospital Trust
发明人： EMERSON, Suzanne U. , SHUKLA, Priyanka , NGUYEN, Hanh T. , PURCELL, Robert H. , DALTON, Harry R. , BENDALL, Richard P.
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/47 , C12N15/86 , C12N2770/28121 , C12N2770/28122 , C12N2770/28134 , C12N2770/28143 , C12N2770/28151 , C12N2770/28152 , C12Q1/707
摘要： The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
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3.发明公开NUCLEOTIDE AND AMINO ACID SEQUENCES OF THE ENVELOPE 1 AND CORE GENES OF HEPATITIS C VIRUS 无效丙型肝炎病毒的包膜蛋白1和核心蛋白的基因的核苷酸序列和氨基酸序列
公开(公告)号：EP0779924A2
公开(公告)日：1997-06-25
申请号：EP95930831.0
申请日：1995-08-15
发明人： BUKH, Jens , MILLER, Roger H. , PURCELL, Robert H.
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12Q1/707 , Y10S435/81
摘要： The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope (1) genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope (1) and core proteins derived from these sequences and their use in diagnostic methods and vaccines.
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4.发明授权NUCLEOTIDE AND AMINO ACID SEQUENCES OF THE ENVELOPE 1 AND CORE GENES OF HEPATITIS C VIRUS 无效丙型肝炎病毒的包膜蛋白1和核心蛋白的基因的核苷酸序列和氨基酸序列
公开(公告)号：EP0779924B1
公开(公告)日：2005-11-09
申请号：EP95930831.3
申请日：1995-08-15
发明人： BUKH, Jens , MILLER, Roger H. , PURCELL, Robert H.
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12Q1/707 , Y10S435/81
摘要： The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope (1) genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope (1) and core proteins derived from these sequences and their use in diagnostic methods and vaccines.
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