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公开(公告)号：EP2582791A2
公开(公告)日：2013-04-24
申请号：EP11796538.4
申请日：2011-06-17
CPC分类号： A61L27/3886 , A61F2/105 , A61K35/36 , A61L27/24 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2501/04 , C12N2501/998 , C12N2502/092 , C12N2502/094 , C12N2502/1323 , C12N2502/30 , C12N2510/00 , C12N2533/78
摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.
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公开(公告)号：EP2582791B1
公开(公告)日：2018-03-28
申请号：EP11796538.4
申请日：2011-06-17
CPC分类号： A61L27/3886 , A61F2/105 , A61K35/36 , A61L27/24 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2501/04 , C12N2501/998 , C12N2502/092 , C12N2502/094 , C12N2502/1323 , C12N2502/30 , C12N2510/00 , C12N2533/78
摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.
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公开(公告)号：EP2991692B1
公开(公告)日：2019-08-21
申请号：EP14728754.4
申请日：2014-05-01
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公开(公告)号：EP2582791B8
公开(公告)日：2018-05-23
申请号：EP11796538.4
申请日：2011-06-17
CPC分类号： A61L27/3886 , A61F2/105 , A61K35/36 , A61L27/24 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2501/04 , C12N2501/998 , C12N2502/092 , C12N2502/094 , C12N2502/1323 , C12N2502/30 , C12N2510/00 , C12N2533/78
摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.
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公开(公告)号：EP2991692A1
公开(公告)日：2016-03-09
申请号：EP14728754.4
申请日：2014-05-01
CPC分类号： A61L27/3886 , A61L27/24 , A61L27/3804 , A61L27/3813 , A61L27/60 , A61L2430/18
摘要： This invention provides compositions in the form of skin substitutes comprising epithelial cells and mesenchymal cells, wherein the mesenchymal cells are not isolated from the occipital or nape region of the scalp, as well as methods for using the same.
摘要翻译： 本发明提供了包含上皮细胞和间充质细胞的皮肤替代物形式的组合物，其中间质细胞不从头皮的枕叶或颈部区域分离，以及使用它们的方法。
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