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公开(公告)号：EP4447791A1
公开(公告)日：2024-10-23
申请号：EP22908480.1
申请日：2022-12-16
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2.发明公开LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA 审中-公开LIPIDFORMULIERUNGEN ZUR FREISETZUNG VON MESSENGER-RNA
公开(公告)号：EP3060257A1
公开(公告)日：2016-08-31
申请号：EP14792713.1
申请日：2014-10-22
CPC分类号： A61K9/1272 , A61K38/1709 , A61K38/177 , A61K38/4846 , A61K38/53 , A61K48/00 , A61K48/0033 , A61K48/005
摘要： The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明尤其提供了在体内递送mRNA的方法，包括向需要递送的受试者施用包含在脂质体内的编码蛋白质的mRNA的组合物，使得组合物的施用导致表达 由mRNA在体内编码的蛋白质，其中所述脂质体包含式Ic阳离子脂质或其药学上可接受的盐。
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公开(公告)号：EP2175980A2
公开(公告)日：2010-04-21
申请号：EP08788645.3
申请日：2008-08-07
发明人： DAVIES, Martyn , ALEXANDER, Morgan , WILLIAMS, Paul , LANGER, Robert , ANDERSON, Daniel , URQUHART, Andrew
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00711 , B01J2219/00716 , B01J2219/00736 , B01J2219/00743 , B82Y30/00 , C12Q1/04
摘要： This invention relates to a method of screening arrays of polymers having pre- determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.
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公开(公告)号：EP3871696A1
公开(公告)日：2021-09-01
申请号：EP21158237.4
申请日：2014-10-22
摘要： The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c:
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：EP3470089A1
公开(公告)日：2019-04-17
申请号：EP18199415.3
申请日：2014-12-12
摘要： The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery particle formulations and/or systems comprising one or more components of a CRISPR-Cas system, which are means for targeting sites for delivery. The delivery particle formulations of the invention are preferably nanoparticle delivery formulations and/or systems. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
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