公开(公告)号：EP2704565B1

公开(公告)日：2018-08-22

申请号：EP12727395.1

申请日：2012-05-04

申请人： The University Of Nottingham ,  Massachusetts Institute of Technology

发明人： WILLIAMS, Paul ,  ALEXANDER, Morgan Russell ,  DAVIES, Martyn Christopher ,  LANGER, Robert ,  ANDERSON, Daniel Griffith

IPC分类号： A01N25/10 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F222/10 ,  C08F220/56

CPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F220/56 ,  C08F222/1006 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  A01N25/10 ,  A01N25/34

摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(=0)-0-]n, R (I) [H2C═CR′—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

公开(公告)号：EP2704565A2

公开(公告)日：2014-03-12

申请号：EP12727395.1

申请日：2012-05-04

申请人： The University Of Nottingham ,  Massachusetts Institute Of Technology

发明人： WILLIAMS, Paul ,  ALEXANDER, Morgan Russell ,  DAVIES, Martyn Christopher ,  LANGER, Robert ,  ANDERSON, Daniel Griffith

IPC分类号： A01N25/10 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F222/10

CPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F220/56 ,  C08F222/1006 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  A01N25/10 ,  A01N25/34

摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR  (I) [H2C═CR′—C(═O)—NH—]nR  (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

公开(公告)号：EP2175980A2

公开(公告)日：2010-04-21

申请号：EP08788645.3

申请日：2008-08-07

申请人： University Of Nottingham ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： DAVIES, Martyn ,  ALEXANDER, Morgan ,  WILLIAMS, Paul ,  LANGER, Robert ,  ANDERSON, Daniel ,  URQUHART, Andrew

IPC分类号： B01J19/00 ,  C40B50/14

CPC分类号： C40B50/14 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00736 ,  B01J2219/00743 ,  B82Y30/00 ,  C12Q1/04

摘要： This invention relates to a method of screening arrays of polymers having pre- determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.

公开(公告)号：EP3766516A1

公开(公告)日：2021-01-20

申请号：EP19201980.0

申请日：2014-03-14

申请人： President and Fellows of Harvard College ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： STARY, Georg ,  RADOVIC-MORENO, Aleksandar Filip ,  BASTO, Pamela A. ,  STARNBACH, Michael N. ,  LANGER, Robert ,  FAROKHZAD, Omid C. ,  ANDRIAN, Ulrich Von

IPC分类号： A61K39/118 ,  A61K45/00 ,  A01N63/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P33/00 ,  A61P37/04

摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.

公开(公告)号：EP2344186B1

公开(公告)日：2017-04-05

申请号：EP09740580.7

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  ALEXIS, Frank ,  BASTO, Pamela ,  MOSEMAN, Ashley ,  SHI, Jinjun ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/39

CPC分类号： A61K39/00 ,  A61K39/0002 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2760/20234

公开(公告)号：EP2968510A1

公开(公告)日：2016-01-20

申请号：EP14770692.3

申请日：2014-03-14

申请人： President and Fellows of Harvard College ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： STARY, Georg ,  RADOVIC-MORENO, Aleksandar, Filip ,  BASTO, Pamela, A. ,  STARNBACH, Michael, N. ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  ANDRIAN, Ulrich, Von

IPC分类号： A61K39/118 ,  A61K45/00 ,  A01N63/00

CPC分类号： A61K39/118 ,  A61K31/4745 ,  A61K31/711 ,  A61K39/0208 ,  A61K39/04 ,  A61K39/085 ,  A61K39/092 ,  A61K45/06 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55572 ,  C12N2740/16034 ,  C12N2760/16134 ,  C12N2760/18534 ,  C12N2770/16034 ,  C12N2770/20034 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/403 ,  Y02A50/466 ,  Y02A50/478 ,  Y02A50/48 ,  Y02A50/484 ,  A61K2300/00

摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.

摘要翻译： 本文提供了包含灭活的病原体和一种或多种辅助剂负载的聚合物纳米粒子的新组合物，其中负载佐剂的纳米粒子与灭活的病原体结合。 这些组合物可用于预防和/或治疗由特定病原体引起的疾病，尤其是当施用于受试者的粘膜时。

公开(公告)号：EP2344187A1

公开(公告)日：2011-07-20

申请号：EP09740582.3

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： SHI, Jinjun ,  ALEXIS, Frank ,  IANNACONE, Matteo ,  MOSEMAN, Ashley ,  BASTO, Pamela ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K47/48869 ,  A61K39/00 ,  A61K47/6925 ,  A61K47/6935

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

公开(公告)号：EP1730286A2

公开(公告)日：2006-12-13

申请号：EP05724526.8

申请日：2005-03-04

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  Lankenau Institute for Medical Research

发明人： ANDERSON, Daniel, Griffith ,  LANGER, Robert ,  SAWICKI, Janet ,  PENG, Weidan

IPC分类号： C12N15/74 ,  A61K31/70

CPC分类号： C12N15/88 ,  A61K48/0058 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/30 ,  C12N2830/008 ,  C12N2830/15

摘要： Aspects of the invention relate to nucleic acids molecules that are useful for specifically destroying selected cells, tissues, or organs. Aspects of the invention are useful for treating diseases (e.g., cancer) that affect cells, tissues, or organs.

公开(公告)号：EP1476255A2

公开(公告)日：2004-11-17

申请号：EP02750237.6

申请日：2002-07-23

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： LAHANN, Jörg ,  LANGER, Robert ,  JENSEN, Klavs, F.

IPC分类号： B05D7/24

CPC分类号： B82Y30/00 ,  B05D1/60 ,  B82Y10/00 ,  C23C16/00 ,  Y10T428/3154 ,  Y10T428/31855

摘要： A method for coating of variable substrates with highly reactive polymers. Its combination with microcontact printing is used for generating several devices such as patterned arrays of ligands for high throughput screening.

公开(公告)号：EP3474852A1

公开(公告)日：2019-05-01

申请号：EP17737130.9

申请日：2017-06-23

申请人： The Charles Stark Draper Laboratory, Inc. ,  Massachusetts Eye & Ear Infirmary ,  Massachusetts Institute of Technology

发明人： BORENSTEIN, Jeffrey T. ,  PARARAS, Erin ,  KIM, Ernest S. ,  TANDON, Vishal ,  AYOOB, Andrew ,  MCKENNA, Michael ,  SEWELL, William ,  PEPPI, Marcello ,  WEINBERG, Marc ,  LANGER, Robert

IPC分类号： A61K31/498 ,  A61K47/10 ,  A61K9/00 ,  A61P27/16