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公开(公告)号：EP3383376A1
公开(公告)日：2018-10-10
申请号：EP16819754.9
申请日：2016-12-01
发明人： HAZEN, Stanley, Leon , GARCIA-GARCIA, Jose Carlos , GERBERICK, George, Franklin , WOS, John, August , STANTON, David, Thomas , INGLIN, Thomas, Alfred , REILLY, Michael , DEUTSCH, Angela, Jane , REED, Jodie, Michelle , CODY, David, Blair
IPC分类号： A61K31/04 , A61K31/095 , A61K31/275 , A61K31/26
CPC分类号： A61K31/26 , A61K31/04 , A61K31/095 , A61K31/145 , A61K31/166 , A61K31/216 , A61K31/22 , A61K31/27 , A61K31/275 , A61K31/325 , A61K31/336 , A61K31/351 , A61K31/439 , A61K31/4425 , A61K31/4453 , A61K31/452 , A61K31/5375 , A61K45/06 , C07C331/20 , C07D211/46 , C07D213/04 , C07D213/30 , C07D213/65 , C07D295/13 , C07D303/36 , C07D453/02 , Y02A50/473
摘要： The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.
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公开(公告)号：EP3522878A1
公开(公告)日：2019-08-14
申请号：EP18792734.8
申请日：2018-10-02
发明人： GARCIA-GARCIA, Jose Carlos , GERBERICK, George, Franklin , WOS, John, August , HAZEN, Stanley, Leon , GU, Xiaodong
IPC分类号： A61K31/14 , A61K31/16 , A61K31/196 , A61K31/198 , A61K31/215 , A61K31/277 , A61K31/5375 , A61K45/06 , A61P3/00 , A61P43/00
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公开(公告)号：EP3522927A1
公开(公告)日：2019-08-14
申请号：EP18792735.5
申请日：2018-10-02
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公开(公告)号：EP3478276A1
公开(公告)日：2019-05-08
申请号：EP17732269.0
申请日：2017-05-31
发明人： HAZEN, Stanley, Leon , GARCIA-GARCIA, Jose Carlos , GERBERICK, George, Franklin , WOS, John, August , GU, Xiandong , REILLY, Michael , SIVIK, Mark, Robert , REED, Jodie, Michelle , CODY, David, Blair
IPC分类号： A61K31/04 , A61K31/275 , A61K31/14 , C07C211/63 , C07C215/40 , C07C217/40 , C07C229/12 , C07C229/30 , A61K31/205
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公开(公告)号：EP3522927B1
公开(公告)日：2020-11-25
申请号：EP18792735.5
申请日：2018-10-02
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公开(公告)号：EP3522876A1
公开(公告)日：2019-08-14
申请号：EP18792732.2
申请日：2018-10-02
发明人： GARCIA-GARCIA, Jose Carlos , GERBERICK, George, Franklin , REILLY, Michael , HAZEN, Stanley, Leon , GU, Xiaodong
IPC分类号： A61K31/095 , A61K31/10 , A61K31/19 , A61K31/275 , A61K31/39 , A61K45/06 , A61P3/00 , A61P43/00
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公开(公告)号：EP3383378A1
公开(公告)日：2018-10-10
申请号：EP16823075.3
申请日：2016-12-01
发明人： HAZEN, Stanley, Leon , GARCIA-GARCIA, Jose Carlos , GERBERICK, George, Franklin , WOS, John, August , STANTON, David, Thomas , INGLIN, Thomas, Alfred , REILLY, Michael , DEUTSCH, Angela, Jane , REED, Jodie, Michelle , CODY, David, Blair
IPC分类号： A61K31/04 , A61K31/095 , A61K31/275 , A61K31/26
CPC分类号： A61K31/26 , A61K31/04 , A61K31/095 , A61K31/145 , A61K31/166 , A61K31/216 , A61K31/22 , A61K31/27 , A61K31/275 , A61K31/325 , A61K31/336 , A61K31/351 , A61K31/439 , A61K31/4425 , A61K31/4453 , A61K31/452 , A61K31/5375 , A61K45/06 , C07C331/20 , C07D211/46 , C07D213/04 , C07D213/30 , C07D213/65 , C07D295/13 , C07D303/36 , C07D453/02 , Y02A50/473
摘要： The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.
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