专利检索 ap:("The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin") AND inv:"CAMPBELL, Matthew" 第 1 页

1.

发明授权
METHOD FOR OPENING TIGHT JUNCTIONS 有权
标题翻译：程序用于打开密封连接

公开(公告)号：EP2209894B1

公开(公告)日：2015-06-03

申请号：EP08837274.3

申请日：2008-10-13

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： HUMPHRIES, Peter , CAMPBELL, Matthew , KIANG, Anna-Sophia

IPC分类号： C12N15/113 , C12N15/11

CPC分类号： C12N15/1138 , A61K31/713 , A61K45/06 , C12N15/111 , C12N2310/14 , C12N2320/31 , C12N2320/32

摘要： The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

2.

发明公开
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE RETINAL CONDITIONS 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VEN DEGENERATIVEN NETZHAUTERKRANKUNGEN

公开(公告)号：EP2760465A1

公开(公告)日：2014-08-06

申请号：EP12772743.6

申请日：2012-10-01

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： CAMPBELL, Matthew , HUMPHRIES, Peter , HUMPHRIES, Marian , KIANG, Anna-Sophia , DOYLE, Sarah , O'NEILL, Luke

IPC分类号： A61K38/20 , A61P27/02

摘要： The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.

摘要翻译： 本发明涉及用于治疗退行性视网膜病症的组合物和方法。根据一般方面，本发明涉及用于治疗涉及玻璃疣和过敏毒素诱导的脉络膜新生血管形成的退行性视网膜病症的炎症介质，优选NLRP3-炎性体的组分或底物。本发明还涉及用于治疗涉及玻璃疣和过敏素诱导的脉络膜新生血管形成的退行性视网膜病症的方法以及用于这些方法的重组载体和重组蛋白。本发明还提供了确定发展或监测涉及玻璃疣和过敏毒素诱导的脉络膜新血管形成疾病进展的风险的方法。