公开(公告)号：EP2509933B1

公开(公告)日：2016-04-20

申请号：EP10787133.7

申请日：2010-12-07

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： CONNON, Stephen Joseph ,  PESCHIULLI, Aldo ,  PROCURANTI, Barbara

IPC分类号： C07B57/00 ,  C07C227/32 ,  C07C229/08 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C319/28 ,  C07C321/10 ,  C07C323/07 ,  C07C323/16 ,  C07C327/22 ,  C07C327/28 ,  C07D453/04

CPC分类号： C07C327/22 ,  C07B57/00 ,  C07B2200/07 ,  C07C51/083 ,  C07C227/32 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C319/28 ,  C07C321/18 ,  C07C327/28 ,  C07D453/04 ,  C07C321/10 ,  C07C229/08 ,  C07C323/16 ,  C07C323/07

摘要： Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols ( i . e ., R-SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

摘要翻译： 虽然醇的动力学拆分方法已经确立，但对硫醇的高选择性，直接催化动力学拆分（即R-SH）没有类似的直接方法。 本发明涉及一种拆分硫醇的立体异构体混合物的方法。 特别地，本发明涉及纯的有机催化介导的硫醇对映体混合物的拆分，而不需要酶。 还公开了一些新型催化剂。 这样的催化剂可以包含来自诱饵生物碱的部分。

公开(公告)号：EP2509933A1

公开(公告)日：2012-10-17

申请号：EP10787133.7

申请日：2010-12-07

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： CONNON, Stephen Joseph ,  PESCHIULLI, Aldo ,  PROCURANTI, Barbara

IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C227/32 ,  C07C229/08 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C321/10 ,  C07C323/07 ,  C07C323/16 ,  C07C327/22 ,  C07C327/28 ,  C07D453/04

CPC分类号： C07C327/22 ,  C07B57/00 ,  C07B2200/07 ,  C07C51/083 ,  C07C227/32 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C319/28 ,  C07C321/18 ,  C07C327/28 ,  C07D453/04 ,  C07C321/10 ,  C07C229/08 ,  C07C323/16 ,  C07C323/07

摘要： Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols ( i . e ., R-SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.