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公开(公告)号：EP2771453A1
公开(公告)日：2014-09-03
申请号：EP12844478.3
申请日：2012-10-26
IPC分类号： C12N1/13 , A61K39/106 , A61K39/112 , C12N15/62
CPC分类号： A61K39/295 , A61K36/06 , A61K39/00 , A61K39/102 , A61K39/107 , A61K2039/51 , A61K2039/517 , A61K2039/523 , A61K2039/541 , A61K2039/542 , A61K2039/57 , C12N1/12 , C12N7/00 , C12N15/79 , C12N2760/18534 , Y02A50/464 , Y02A50/472 , Y02A50/487
摘要： This invention provides diatom-based vaccines.
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2.发明公开METHOD FOR IDENTIFICATION OF PROTEASE ACTIVITY INHIBITORS AND ASSAYING THE PRESENCE OF PROTEASE ACTIVITY 审中-公开一种用于识别蛋白酶活性酶抑制剂和蛋白酶活动的发生调查
公开(公告)号：EP2510107A2
公开(公告)日：2012-10-17
申请号：EP10836574.3
申请日：2010-12-07
CPC分类号： C12Q1/37 , C12N15/1034 , C12N15/1086 , C12N15/635 , C12Q1/6897 , C12Q2522/101 , C12Q2521/537
摘要： A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression of the reporter gene(s) in functional coordination with a transcriptional activation agent. The second component is a transcriptional activation agent comprising a nucleic acid binding domain, at least one protease substrate domain, and at least one transcriptional activation domain for an inducible promoter. The system allows detection and evaluation of agents affecting protease activity directed to the protease substrate domain. The system also allows for the detection of the presence of proteases in environmental samples.
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3.发明公开A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS 审中-公开新的蛋白质释放系统产生感应干细胞或组织特异性细胞多能性
公开(公告)号：EP2470664A2
公开(公告)日：2012-07-04
申请号：EP10815904.7
申请日：2010-08-27
发明人： CHANG, Yung-Nien , OYLER, George A.
CPC分类号： C12N5/0696 , A61K35/74 , A61K38/164 , C07K14/33 , C07K14/4702 , C07K2319/00 , C07K2319/10 , C07K2319/55 , C12N5/00 , C12N2501/602 , C12N2501/603
摘要： A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell.
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公开(公告)号：EP4014039A1
公开(公告)日：2022-06-22
申请号：EP20775934.1
申请日：2020-08-13
发明人： OYLER, George A. , GERTZ, Barry
IPC分类号： G01N33/50 , G01N33/542 , C07K14/33
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公开(公告)号：EP3980532A1
公开(公告)日：2022-04-13
申请号：EP20743768.2
申请日：2020-06-08
发明人： OYLER, George A. , GERTZ, Barry
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6.发明公开SINGLE CHAIN ANTIBODIES FOR PHOTOSYNTHETIC MICROORGANISMS AND METHODS OF USE 审中-公开对于照片合成微生物的单链抗体及其使用方法
公开(公告)号：EP2694543A2
公开(公告)日：2014-02-12
申请号：EP12767799.5
申请日：2012-04-07
CPC分类号： C07K16/14 , C07K2317/22 , C07K2317/569 , C07K2319/00 , C07K2319/20 , C07K2319/70 , C12N1/02 , C12N1/12 , C12N1/22
摘要： A single chain antibody that binds algae is described. The single chain antibody for algae is used to capture algae onto bioactive films. The single chain antibody is also used in a chimeric construct having a substrate binding domain and a single chain antibody domain. Dimers, trimmers, and multimer constructs are also described that aid in collection of algae from liquid mixtures by causing flocculation of algae cells.
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公开(公告)号：EP2580345A2
公开(公告)日：2013-04-17
申请号：EP11831073.9
申请日：2011-06-13
发明人： OYLER, George A. , TSAI, Yien Che
CPC分类号： C12Q1/66 , C12Q1/37 , G01N2333/33 , G01N2333/952 , G01N2500/10
摘要： A cell based assay for detection for protease activity is disclosed. In the assay a cell is engineered to express a protease substrate with at least one label, preferably on its C-terminus. Cleavage of the substrate by the protease that recognizes it results in a C-terminal fragment and a N-terminal fragment, where the fragment having the label is subject to ubiquitin proteasome degradation. The assay measures the disappearance of the label due to degradation of the fragment to which it is attached. A cell free assay is also described for detection of protease activity. In the cell free assay, the protease substrate is expressed in a solution that includes the elements of the ubiquitin proteasome pathway for degradation of the fragment. The assay measures the disappearance of the label attached to the fragment that results from cleavage by the protease.
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