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1.发明公开Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权Adenoassoziierte Virus-Claden，Sequenzen，diese enthaltende Vektoren und ihre Verwendungen
公开(公告)号：EP2345731A1
公开(公告)日：2011-07-20
申请号：EP10182098.3
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译： 提供腺相关病毒衣壳和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。 还提供使用本发明的载体的AAV介导的治疗和免疫原性基因的递送。
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2.发明公开Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 审中-公开进化枝（亚型）和腺相关病毒（AAV）的序列，含有这些载体和它们的用途
公开(公告)号：EP2298926A1
公开(公告)日：2011-03-23
申请号：EP10183929.8
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译： 提供腺相关病毒衣壳和载体和含合成序列的宿主细胞的序列。 所以描述的是在生产rAAV颗粒的使用这样的宿主细胞和载体的方法。 因此使用本发明的载体的治疗和免疫原性的基因的AAV介导的递送提供。
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3.发明授权Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权腺相关病毒的进化枝，含有这些载体和它们的用途的序列
公开(公告)号：EP2345731B1
公开(公告)日：2015-10-21
申请号：EP10182098.3
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
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4.发明授权Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues 有权用于从细胞组织整合的病毒DNA的直接回收和扩增方法
公开(公告)号：EP1359217B1
公开(公告)日：2006-12-13
申请号：EP03252519.8
申请日：2003-04-22
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2750/14143 , C12N2750/14151
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5.发明公开Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues 有权用于从细胞组织整合的病毒DNA的直接回收和扩增方法
公开(公告)号：EP1359217A1
公开(公告)日：2003-11-05
申请号：EP03252519.8
申请日：2003-04-22
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2750/14143 , C12N2750/14151
摘要： A method for isolating AAV viruses from cellular DNA of mammalian tissues comprises transfecting the digested DNA into cells, rescuing the virus and amplifying it through serial passages in the presence of adenovirus helper functions. Kits useful for performing this method are also provided.
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