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1.发明授权Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权腺相关病毒的进化枝，含有这些载体和它们的用途的序列
公开(公告)号：EP2345731B1
公开(公告)日：2015-10-21
申请号：EP10182098.3
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
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公开(公告)号：EP2359865A1
公开(公告)日：2011-08-24
申请号：EP10179260.4
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译： 提供了校正选择的AAV序列中的单体以提高所选AAV的包装产量，转导效率和/或基因转移效率的方法。 该方法涉及改变亲代AAV衣壳中的一个或多个单体以使单体与排列的功能性AAV衣壳序列的相应位置中的氨基酸一致。
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3.发明公开Simian adenoviruses SAdV-36, -42.1, -42.2, AND -44 and uses thereof 有权丝棉SADV-36，-42.1，-42.2，-44和及其使用
公开(公告)号：EP2325298A3
公开(公告)日：2012-08-29
申请号：EP10186684.6
申请日：2009-03-03
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K39/145 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10371 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： An adenovirus is disclosed, having a capsid comprising a hexon protein of SAdV-42.1 or an amino acid sequence at least about 99% identical thereto, or a hybrid hexon protein. The capsid encapsidates a heterologous nucleic acid molecule carrying a gene sequence operably linked to expression control sequences which direct transcription, translation, and/or expression in a host cell, and further encapsidates 5' and 3' adenovirus cis-elements necessary for replication and encapsidation.
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4.发明公开Method of increasing the function of an AAV vector 有权Modifizierte AAV rh48 Kapside，Kompositionen die solche enthalten und dessen Verwendung
公开(公告)号：EP2359866A1
公开(公告)日：2011-08-24
申请号：EP10179330.5
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译： 提供了一种校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。 该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能AAV衣壳序列的相应位置中的氨基酸一致。
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5.发明公开Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权Adenoassoziierte Virus-Claden，Sequenzen，diese enthaltende Vektoren und ihre Verwendungen
公开(公告)号：EP2345731A1
公开(公告)日：2011-07-20
申请号：EP10182098.3
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译： 提供腺相关病毒衣壳和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。 还提供使用本发明的载体的AAV介导的治疗和免疫原性基因的递送。
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6.发明公开Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权含有它们和其用途进化枝和腺相关病毒的序列（AAV）载体
公开(公告)号：EP2292779A3
公开(公告)日：2011-03-30
申请号：EP10182587.5
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译： 提供腺相关病毒衣壳和载体和含合成序列的宿主细胞的序列。 所以描述的是在生产rAAV颗粒的使用这样的宿主细胞和载体的方法。 因此使用本发明的载体的治疗和免疫原性的基因的AAV介导的递送提供。
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公开(公告)号：EP2359865B1
公开(公告)日：2013-10-02
申请号：EP10179260.4
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
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8.发明授权Method of increasing the function of an AAV vector 有权Verfahren zurErhöhungder Funktion eines AAV-Vektors
公开(公告)号：EP2357010B1
公开(公告)日：2013-06-12
申请号：EP10179347.9
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译： 提供了一种校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。 该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能AAV衣壳序列的相应位置中的氨基酸一致。
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公开(公告)号：EP2383346A1
公开(公告)日：2011-11-02
申请号：EP10184600.4
申请日：2006-04-07
IPC分类号： C12N15/864 , C12N7/00 , A61K35/76 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
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公开(公告)号：EP2359867A1
公开(公告)日：2011-08-24
申请号：EP10179534.2
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
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