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公开(公告)号：EP2294420B1
公开(公告)日：2015-08-12
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP2294420A2
公开(公告)日：2011-03-16
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health&Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, George , WYNDHAM, Wilson H. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP2294420B8
公开(公告)日：2015-10-21
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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4.发明公开
公开(公告)号：EP2050035A2
公开(公告)日：2009-04-22
申请号：EP07810823.0
申请日：2007-07-25
申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency (BCCA) , Catalan Institute of Oncology , Rikshospitalet-RadiumHospitalet Medical Center , St. Bartholomew's Hospital , University of Arizona Cancer Center , University of Barcelona , University of Nebraska Medical Center , University of Rochester Medical Center , University of Würzburg , Powell, John I.
发明人： STAUDT, Louis M. , WRIGHT, George , DAVE, Sandeep , TAN, Bruce , WILSON, Wyndham , JAFFE, Elaine , CHAN, Wing C. , GREINER, Timothy C. , WEISSENBURGER, Dennis , ARMITAGE, James , FU, Kai , FISHER, Richard , RIMSZA, Lisa , MILLER, Thomas , GROGAN, Thomas , CAMPO, Elias , BEA, Silvia M. , SALAVERRIA, Itziar , LOPEZ-GUILLERMO, Armando , MONTSERRAT, Emili , MORENO, Victor , ZETTL, Andreas , OTT, German , MULLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , VOSE, Julie , GASCOYNE, Randy , CONNORS, Joseph , SMELAND, Erlend , KVALOY, Stein , HOLTE, Harald , DELABIE, Jan , LISTER, T. Andrew
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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