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公开(公告)号：EP2294420A2
公开(公告)日：2011-03-16
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health&Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, George , WYNDHAM, Wilson H. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP2294420B1
公开(公告)日：2015-08-12
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP2294420B8
公开(公告)日：2015-10-21
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP3445873B1
公开(公告)日：2020-11-04
申请号：EP17724960.4
申请日：2017-04-20
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Wuerzburg , Oregon Health & Science University , Hospital Clínic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： STAUDT, Louis M. , SCOTT, David William , WRIGHT, George W. , ROSENWALD, Andreas , ABRISQUETA, Pau , BRAZIEL, Rita M. , CAMPO GUERRI, Elias , CHAN, Wing C. , CONNORS, Joseph M. , DELABIE, Jan , VILLA, Diego , FU, Kai , GASCOYNE, Randy D. , GREINER, Timothy C. , JAFFE, Elaine S. , JARES, Pedro , MOTTOK, Anja , OTT, German , RIMSZA, Lisa M. , SLACK, Graham , WEISENBURGER, Dennis D. , SMELAND, Erlend B. , COOK, James Robert
IPC分类号： A61P7/00 , A61P35/00 , A61P35/02 , C12Q1/6886
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公开(公告)号：EP3594359A1
公开(公告)日：2020-01-15
申请号：EP19170689.4
申请日：2014-11-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：EP3066215B1
公开(公告)日：2019-04-24
申请号：EP14803288.1
申请日：2014-11-05
申请人： The United States of America, represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
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7.发明公开METHOD FOR SUBTYPING LYMPHOMA TYPES BY MEANS OF EXPRESSION PROFILING 审中-公开VERFAHREN ZUR SUBTYPISIERUNG VON LYMPHOMTYPEN MITTELS EXPRESSIONSPROFILIERUNG
公开(公告)号：EP3066215A1
公开(公告)日：2016-09-14
申请号：EP14803288.1
申请日：2014-11-05
申请人： The United States of America, represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/166 , G06F19/12
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样弥漫性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活组织检查样品。
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公开(公告)号：EP3638814A1
公开(公告)日：2020-04-22
申请号：EP18733500.5
申请日：2018-06-05
申请人： The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer , British Columbia Cancer Agency Branch , Mayo Foundation for Medical Education and Research , Julius-Maximilians-Universitaet Wuerzburg , The Board of Regents of the University of Nebraska , Oslo University Hospital HF , University of Health Network , Hospital Clinic De Barcelona , Universitat de Barcelona , Institut D'Investigacions Biomèdiques August Pi I Sunyer - IDIBAPS , Robert Bosch Gesellschaft für medizinische Forschung mbH , Oregon Health & Science University , City of Hope , The Cleveland Clinic Foundation
发明人： STAUDT, Louis M. , STEIDL, Christian , MOTTOK, Anja , WRIGHT, George W. , SCOTT, David William , RIMSZA, Lisa M. , ROSENWALD, Andreas , GASCOYNE, Randy , GREINER, Timothy , WEISENBURGER, Dennis , SMELAND, Erlend B. , DELABIE, Jan , CAMPO GUERRI, Elias , OTT, German , BRAZIEL, Rita , JAFFE, Elaine S. , FU, Kai , CHAN, Wing C. , SONG, Joo , COOK, James R.
IPC分类号： C12Q1/6886
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9.发明公开
公开(公告)号：EP2050035A2
公开(公告)日：2009-04-22
申请号：EP07810823.0
申请日：2007-07-25
申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency (BCCA) , Catalan Institute of Oncology , Rikshospitalet-RadiumHospitalet Medical Center , St. Bartholomew's Hospital , University of Arizona Cancer Center , University of Barcelona , University of Nebraska Medical Center , University of Rochester Medical Center , University of Würzburg , Powell, John I.
发明人： STAUDT, Louis M. , WRIGHT, George , DAVE, Sandeep , TAN, Bruce , WILSON, Wyndham , JAFFE, Elaine , CHAN, Wing C. , GREINER, Timothy C. , WEISSENBURGER, Dennis , ARMITAGE, James , FU, Kai , FISHER, Richard , RIMSZA, Lisa , MILLER, Thomas , GROGAN, Thomas , CAMPO, Elias , BEA, Silvia M. , SALAVERRIA, Itziar , LOPEZ-GUILLERMO, Armando , MONTSERRAT, Emili , MORENO, Victor , ZETTL, Andreas , OTT, German , MULLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , VOSE, Julie , GASCOYNE, Randy , CONNORS, Joseph , SMELAND, Erlend , KVALOY, Stein , HOLTE, Harald , DELABIE, Jan , LISTER, T. Andrew
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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