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1.发明公开COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR THERAPIE UND DIORNOSE VON GRIPPE
公开(公告)号：EP2988781A2
公开(公告)日：2016-03-02
申请号：EP14788677.4
申请日：2014-04-18
发明人： HAMMOND, Phil , GRANDEA, Andres G. , KING, Gordon , COX, Thomas C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew
IPC分类号： A61K39/42
CPC分类号： C07K16/1018 , A61K31/215 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新型人类抗流感抗体及相关组合物和方法。 这些抗体用于诊断和治疗流行性感冒。
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公开(公告)号：EP2685968A1
公开(公告)日：2014-01-22
申请号：EP12709488.6
申请日：2012-03-13
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
CPC分类号： A61K31/215 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K16/1018 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92 , A61K2300/00
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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3.发明授权COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF CYTOMEGALOVIRUS INFECTIONS 有权组合物和方法用于治疗和巨细胞病毒感染的诊断
公开(公告)号：EP2257571B1
公开(公告)日：2015-03-04
申请号：EP09720032.3
申请日：2009-03-10
发明人： OLSEN, Ole
IPC分类号： C07K16/08
CPC分类号： C07K16/088 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56994 , G01N2333/045
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公开(公告)号：EP2432803A2
公开(公告)日：2012-03-28
申请号：EP10732514.4
申请日：2010-05-20
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/56983
摘要： The present invention provides novel human anti- influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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公开(公告)号：EP2611465A2
公开(公告)日：2013-07-10
申请号：EP11822530.9
申请日：2011-08-31
申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International Aids Vaccine Initiative
发明人： CHAN-HUI, Po-ying , DOORES, Katherine , HUBER, Michael , KAMINSKY, Stephen , FREY, Steven , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , PHOGAT, Sanjay K. , BURTON, Dennis R. , WALKER, Laura Marjorie , POIGNARD, Pascal Raymond Georges , KOFF, Wayne , SIMEK-LEMOS, Melissa Danielle, de Jean de St. Marcel
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
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公开(公告)号：EP2603237A2
公开(公告)日：2013-06-19
申请号：EP11817092.7
申请日：2011-08-12
IPC分类号： A61K39/395 , A61K39/145 , C07K16/28 , A61P31/16 , A61P31/00
CPC分类号： C07K16/1018 , A61K39/395 , A61K39/42 , A61K45/06 , A61K47/48384 , A61K47/4853 , A61K47/6803 , A61K47/6841 , A61K49/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11 , G01N2469/10 , A61K2300/00
摘要： The present invention provides novel human anti -Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.
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7.发明公开COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF CYTOMEGALOVIRUS INFECTIONS 有权组合物和方法用于治疗和巨细胞病毒感染的诊断
公开(公告)号：EP2257571A2
公开(公告)日：2010-12-08
申请号：EP09720032.3
申请日：2009-03-10
发明人： OLSEN, Ole
IPC分类号： C07K16/08
CPC分类号： C07K16/088 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56994 , G01N2333/045
摘要： The present invention provides novel anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
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公开(公告)号：EP2408476B1
公开(公告)日：2017-10-18
申请号：EP10722810.8
申请日：2010-03-17
申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International AIDS Vaccine Initiative
发明人： CHAN-HUI, Po-Ying , MITCHAM, Jennifer , OLSEN, Ole , FREY, Steven , MOYLE, Matthew , PHOGAT, Sanjay, K. , BURTON, Dennis, R. , WALKER, Laura, Marjorie , POIGNARD, Pascal, Raymond, Georges , DE JEAN DE ST.MARCEL SIMEK-LEMOS, Melissa, D. , KOPF, Wayne , KAMINSKY, Stephen
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
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公开(公告)号：EP2675478A2
公开(公告)日：2013-12-25
申请号：EP12747475.7
申请日：2012-02-14
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17 , A61P31/16 , A61P31/00
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/76 , G01N33/54306 , G01N33/56983 , G01N2333/11
摘要： The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
摘要翻译： 本发明提供了使用抗流感血凝素和基质2胞外域多肽的抗体组合来诊断，治疗和预防流感感染的组合物，疫苗和方法。
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10.发明公开HUMAN IMMUNODEFICIENCY VIRUS (HIV) -NEUTRALIZING ANTIBODIES 有权DAS HUMANEIMMUNSCHWÄCHEVIRUS（艾滋病毒）中性粒细胞抗体
公开(公告)号：EP2408476A2
公开(公告)日：2012-01-25
申请号：EP10722810.8
申请日：2010-03-17
申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International AIDS Vaccine Initiative
发明人： CHAN-HUI, Po-Ying , MITCHAM, Jennifer , OLSEN, Ole , FREY, Steven , MOYLE, Matthew , PHOGAT, Sanjay, K. , BURTON, Dennis, R. , WALKER, Laura, Marjorie , POIGNARD, Pascal, Raymond, Georges , DE JEAN DE ST.MARCEL SIMEK-LEMOS, Melissa, D. , KOPF, Wayne , KAMINSKY, Stephen
IPC分类号： A61K39/118 , A61K39/39 , C07K16/10
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以对多种HIV-1物质进行中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得到的单克隆抗体的特征在于其以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染的能力。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位的免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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