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1.发明公开METHODS AND MEANS FOR ASSESSING HIV GAG/PROTEASE INHIBITOR THERAPY 审中-公开的方法和手段进行评估HIV GAG /蛋白酶抑制剂治疗
公开(公告)号：EP2010680A2
公开(公告)日：2009-01-07
申请号：EP07765259.2
申请日：2007-04-13
发明人： DE BAERE, Inky Paul Madeleine , KRAUS, Guenter , RIMSKY, Laurence Tatiana , MAES, Bart Anna Julien , AZIJN, Hilde , DE BETHUNE, Marie-Pierre T.M.M.G
CPC分类号： C12Q1/703 , G01N2333/161
摘要： The present invention relates to methods and means for the evaluation of HIV treatment. In particular, molecular events at the HIV gag and protease proteins and their effect on therapeutic efficacy of drugs are determined. The methods rely on providing HIV gag and protease nucleic acid material and evaluating a treatment either through genotyping or phenotyping. Said method may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
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2.发明授权
公开(公告)号：EP1946111B1
公开(公告)日：2009-05-13
申请号：EP06807247.9
申请日：2006-10-13
发明人： RIMSKY, Laurence Tatiana , VAN MARCK, Herwig Gaston Emiel , DE BETHUNE, Marie-Pierre T.M.M.G. , BACHELER, Lee Terry
IPC分类号： G01N33/569 , G06F19/00
CPC分类号： G01N33/56983 , G01N2800/52 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to methods and means for determining the replication rate of a viral population. More specifically, the invention provides methods and means for determining the replication rate of a viral population by performing a linear regression on signal data generated by cells infected with dilutions of the viral population. The methods are useful for monitoring the progression of diseases associated with viruses, identifying effective drug regimens for the treatment of viral infections, and identifying and determining the biological effectiveness of potential therapeutic compounds.
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3.发明公开
公开(公告)号：EP1960554A1
公开(公告)日：2008-08-27
申请号：EP06841303.8
申请日：2006-12-07
发明人： RIMSKY, Laurence Tatiana , DE BAERE, Inky Paul Madeleine , MAES, Bart Anna Julien , DE BETHUNE, Marie-Pierre T.M.M.G , KRAUS, Guenter , MOKANY, Elisa , TODD, Alison Velyian
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703
摘要： The present invention relates to methods and means for the evaluation of HIV replicat ive capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and probes, and the generation of replication-competent viruses therefrom. Said methods and materials may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
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4.发明公开
公开(公告)号：EP1946111A1
公开(公告)日：2008-07-23
申请号：EP06807247.9
申请日：2006-10-13
发明人： RIMSKY, Laurence Tatiana , VAN MARCK, Herwig Gaston Emiel , DE BETHUNE, Marie-Pierre T.M.M.G. , BACHELER, Lee Terry
IPC分类号： G01N33/569 , G06F19/00
CPC分类号： G01N33/56983 , G01N2800/52 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to methods and means for determining the replication rate of a viral population. More specifically, the invention provides methods and means for determining the replication rate of a viral population by performing a linear regression on signal data generated by cells infected with dilutions of the viral population. The methods are useful for monitoring the progression of diseases associated with viruses, identifying effective drug regimens for the treatment of viral infections, and identifying and determining the biological effectiveness of potential therapeutic compounds.
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