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1.发明授权NUCLEIC ACID AND GENE ORIGINATING IN NOVEL HCV STRAIN AND REPLICON-REPLICATING CELL USING THE GENE 有权从HCV核酸和始发GEN的新菌株和基因USED复制子复制细胞
公开(公告)号：EP1666598B1
公开(公告)日：2015-08-12
申请号：EP04773387.8
申请日：2004-09-16
CPC分类号： C07K14/005 , C12N7/00 , C12N15/67 , C12N15/86 , C12N2770/24221 , C12N2770/24222 , C12N2840/203
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2.发明授权NUCLEIC ACID CONSTRUCT CONTAINING FULL-LENGTH GENOME OF HUMAN HEPATITIS C VIRUS, RECOMBINANT FULL-LENGTH VIRUS GENOME REPLICATIVE CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO AND METHOD OF CONSTRUCTING HEPATITIS C VIRAL PARTICLES 有权与VOLLÄNGENGENOM人丙型肝炎病毒，重组病毒基因组全长滚动细胞透过您在施工丙型肝炎病毒颗粒传送核构建和方法的核构建
公开(公告)号：EP1721985B1
公开(公告)日：2010-06-30
申请号：EP05719575.2
申请日：2005-02-21
发明人： WAKITA, Takaji , KATO, Takanobu , DATE, Tomoko; , MIYAMOTO, Michiko; , TANABE, Jun-ichi , SONE, Saburo;
IPC分类号： C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/01 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/567 , C07K16/08 , A61K35/76 , A61P37/04
CPC分类号： C12N7/00 , A61K2039/525 , C07K16/109 , C12N15/86 , C12N2770/24221 , C12N2770/24243 , C12N2840/203 , G01N33/5767
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3.发明公开NUCLEIC ACID CONSTRUCT CONTAINING HEPATITIS C VIRUS (HCV) OF GENOCYPE 2a GENOME-ORIGIN NUCLEIC ACID AND CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO 有权从丙型肝炎病毒（HCV）基因型2a ORIGINATING的含有核酸和核酸构建体的细胞与该核酸在基因组的构建体到其中TRANSFERRED
公开(公告)号：EP1627917A1
公开(公告)日：2006-02-22
申请号：EP03774223.6
申请日：2003-11-25
申请人： TORAY INDUSTRIES, INC. , Tokyo Metropolitan Organization for Medical Research , Johannes Gutenberg-Universität Mainz
发明人： WAKITA, Takaji , KATO, Takanobu , DATE, Tomoko
CPC分类号： C07K14/08 , C07K14/005 , C12N2770/24222
摘要： The present invention relates to a replicon RNA comprising a nucleotide sequence at least containing the 5' untranslated region, the nucleotide sequence encoding NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein, and the 3' untranslated region on the genomic RNA of hepatitis C virus of genotype 2a.
摘要翻译： 本发明涉及一种复制子RNA，其包含至少含有5的核苷酸序列的“非翻译区，编码NS3蛋白，NS4A蛋白，NS4B蛋白，NS5A蛋白和NS5B蛋白和3的核苷酸序列”在基因组RNA翻译区 的基因型2a的丙型肝炎病毒。
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4.发明授权NUCLEIC ACID CONSTRUCT CONTAINING HEPATITIS C VIRUS (HCV) OF GENOCYPE 2a GENOME-ORIGIN NUCLEIC ACID AND CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO 有权从丙型肝炎病毒（HCV）基因型2a ORIGINATING的含有核酸和核酸构建体的细胞与该核酸在基因组的构建体到其中TRANSFERRED
公开(公告)号：EP1627917B1
公开(公告)日：2010-06-16
申请号：EP03774223.6
申请日：2003-11-25
申请人： TORAY INDUSTRIES, INC. , Tokyo Metropolitan Organization for Medical Research , Bartenschlager, Ralf
发明人： WAKITA, Takaji , KATO, Takanobu , DATE, Tomoko
CPC分类号： C07K14/08 , C07K14/005 , C12N2770/24222
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5.发明公开NUCLEIC ACID AND GENE ORIGINATING IN NOVEL HCV STRAIN AND REPLICON-REPLICATING CELL USING THE GENE 有权从HCV核酸和始发GEN的新菌株和基因USED复制子复制细胞
公开(公告)号：EP1666598A1
公开(公告)日：2006-06-07
申请号：EP04773387.8
申请日：2004-09-16
CPC分类号： C07K14/005 , C12N7/00 , C12N15/67 , C12N15/86 , C12N2770/24221 , C12N2770/24222 , C12N2840/203
摘要： The present invention relates to a gene derived from a novel fulminant hepatitis C virus strain, an HCV replicon RNA with a high replication efficiency obtained using the gene, and an HCV replicon-replicating cell transfected with the replicon RNA. When the HCV replicon RNA and the HCV replicon-replicating cell of the present invention are used, HCV proteins can be continuously produced in a large amount.
摘要翻译： 本发明涉及由一种新型的暴发性丙型肝炎病毒株，使用酶的基因获得高复制效率的HCV复制子RNA的，基因，和在HCV复制子复制细胞与复制子RNA转染。 当使用HCV复制子RNA和本发明的所述HCV复制子复制细胞，HCV蛋白可以大量连续生产。
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