公开(公告)号：EP1598067B1

公开(公告)日：2009-05-06

申请号：EP05015737.9

申请日：2001-09-27

申请人： TopoTarget UK Limited

发明人： Watkins, Clare J. ,  Romero-Martin, Maria-Rosario ,  Moore, Kathryn G. ,  Ritchie, James ,  Finn, Paul W. ,  Kalvinsh, Ivars Latvian Inst. of Org. Synthesis ,  Loza, Einars Latvian Inst. of Org. Synthesis ,  Starchenkov, Igor Latvian Inst. of Org. Synthesis ,  Dikovska, Klara Latvian Inst. of Org. Synthesis ,  Bokaldere, Rasma Melita ,  Gailite, Vija Latvian Inst. of Org. Synthesis ,  Vorona, Maxim Latvian Inst. of Org. Synthesis ,  Andrianov, Victor Latvian Inst. of Org. Synthesis ,  Lolya, Daina Latvian Inst. of Org. Synthesis ,  Semenikhina, Valentina ,  Amolins, Andris Latvian Inst. of Org. Synthesis ,  Harris, John C. BioFocus Discovery ,  Duffy, James, E. S.

IPC分类号： A61K31/426 ,  A61K31/381 ,  A61K31/38 ,  A61K31/277 ,  A61K31/198 ,  A61K31/195 ,  A61K31/16 ,  A61P31/20

CPC分类号： C07D207/337 ,  A61K31/16 ,  A61K31/195 ,  A61K31/198 ,  A61K31/277 ,  A61K31/38 ,  A61K31/381 ,  A61K31/426 ,  C07C233/49 ,  C07C233/83 ,  C07C235/34 ,  C07C237/36 ,  C07C255/57 ,  C07C259/06 ,  C07C259/08 ,  C07C2603/18 ,  C07D207/40 ,  C07D207/404 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/22 ,  C07D213/06 ,  C07D213/55 ,  C07D213/56 ,  C07D233/04 ,  C07D233/08 ,  C07D235/14 ,  C07D235/24 ,  C07D271/06 ,  C07D307/34 ,  C07D307/54 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07D403/12 ,  Y02A50/411

摘要： This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: wherein: A is an aryl group; Q is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR C(=O)- and -C(=O)NR -; R is an amido substituent; and, Q is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof, for use in the treatment of parasitic infections, such as malaria.