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1.发明公开CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF 有权CYCLOHEXANDERIVAT UND PHARMAZEUTISCHE ANWENDUNG DAVON
公开(公告)号：EP2341047A1
公开(公告)日：2011-07-06
申请号：EP09823687.0
申请日：2009-10-30
发明人： MORITA, Yasuhiro , ISEKI, Katsuhiko , SUGAWARA, Yuji , TSUTSUI, Hideyuki , IWANO, Shunsuke , IZUMIMOTO, Naoki , ARAI, Tadamasa , NODA, Hidetoshi , YOSHIDA, Chihiro
IPC分类号： C07D231/12 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , A61P25/04 , A61P29/02 , C07D263/32 , C07D277/24 , C07D401/04
CPC分类号： A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D263/32 , C07D277/24 , C07D401/04
摘要： The present invention aims to provide a compound having a strong analgesic action against both nociceptive pain and neuropathic pain and having less side effects, and a medical use thereof. The present invention provides cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.
摘要翻译： 本发明的目的在于提供一种对伤害性疼痛和神经性疼痛具有强镇痛作用并具有较少副作用的化合物及其医疗用途。 本发明提供由以下化合物或其药学上可接受的盐或其前药代表的环己烷衍生物。
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2.发明公开UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 审中-公开UREIDDERIVAT UND DESSEN VERWENDUNGFÜRMEDISINISCHE ZWECKE
公开(公告)号：EP2009006A1
公开(公告)日：2008-12-31
申请号：EP07739727.1
申请日：2007-03-27
IPC分类号： C07D263/48 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/46 , A61K31/496 , A61P25/04 , A61P29/00 , C07D277/20 , C07D277/42 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D451/02
CPC分类号： C07D263/48 , C07D277/20 , C07D277/42 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D451/02
摘要： This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula:
or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.摘要翻译： 本发明涉及一种药物，其包含作为活性成分的由式：或其药学上可接受的盐表示的酰脲衍生物。 根据本发明的酰脲衍生物或其药学上可接受的盐可用于缓解疼痛和治疗或预防神经性疼痛。
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公开(公告)号：EP2341047B1
公开(公告)日：2014-10-15
申请号：EP09823687.0
申请日：2009-10-30
发明人： MORITA, Yasuhiro , ISEKI, Katsuhiko , SUGAWARA, Yuji , TSUTSUI, Hideyuki , IWANO, Shunsuke , IZUMIMOTO, Naoki , ARAI, Tadamasa , NODA, Hidetoshi , YOSHIDA, Chihiro
IPC分类号： C07D231/12 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , A61P25/04 , A61P29/02 , C07D263/32 , C07D277/24 , C07D401/04
CPC分类号： A61K31/415 , A61K31/421 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D263/32 , C07D277/24 , C07D401/04
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公开(公告)号：EP3345893B1
公开(公告)日：2019-10-30
申请号：EP16841903.4
申请日：2016-08-31
发明人： NISHIO, Yukihiro , KUBOTA, Yuko , YAMAMOTO, Masashi , NISHIMURA, Yutaka , MASUDA, Tomohide , TSUTSUI, Hideyuki , OKIMURA, Keiichi , UDAGAWA, Syuji , KAINO, Mie , MEGURO, Hiroyuki , SEKIYA, Yumiko
IPC分类号： C07C275/34 , A61K31/17 , A61K31/4406 , A61K31/4409 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/50 , A61K31/506 , A61K31/513 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D213/30 , C07D213/65 , C07D213/74 , C07D237/14 , C07D239/34 , C07D239/47 , C07D401/04
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公开(公告)号：EP3345892A1
公开(公告)日：2018-07-11
申请号：EP16841901.8
申请日：2016-08-31
发明人： NISHIO, Yukihiro , YAMAMOTO, Masashi , KUBOTA, Yuko , TSUTSUI, Hideyuki , MASUDA, Tomohide , OKIMURA, Keiichi , UDAGAWA, Syuji , KAINO, Mie , MEGURO, Hiroyuki , SEKIYA, Yumiko
IPC分类号： C07C275/34 , A61K31/17 , A61K31/192 , A61K31/235 , A61K31/337 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4465 , A61K31/455 , A61K31/495 , A61K31/506 , A61P35/00 , A61P35/02 , A61P43/00 , C07C275/30 , C07C275/32 , C07D211/46 , C07D213/30 , C07D213/68
CPC分类号： A61K31/17 , A61K31/192 , A61K31/235 , A61K31/337 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4465 , A61K31/455 , A61K31/495 , A61K31/506 , C07C275/30 , C07C275/32 , C07C275/34 , C07D211/46 , C07D213/30 , C07D213/68 , C07D213/81 , C07D213/82 , C07D305/08 , C07D403/04
摘要： The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3345893A1
公开(公告)日：2018-07-11
申请号：EP16841903.4
申请日：2016-08-31
发明人： NISHIO, Yukihiro , KUBOTA, Yuko , YAMAMOTO, Masashi , NISHIMURA, Yutaka , MASUDA, Tomohide , TSUTSUI, Hideyuki , OKIMURA, Keiichi , UDAGAWA, Syuji , KAINO, Mie , MEGURO, Hiroyuki , SEKIYA, Yumiko
IPC分类号： C07C275/34 , A61K31/17 , A61K31/4406 , A61K31/4409 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/50 , A61K31/506 , A61K31/513 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D213/30 , C07D213/65 , C07D213/74 , C07D237/14 , C07D239/34 , C07D239/47 , C07D401/04
摘要： The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.
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