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1.发明公开PRODUCTION OF RECOMBINANT FRAGMENTS OF MUSCLE ACETYLCHOLINE RECEPTOR AND THEIR USE FOR EX VIVO IMMUNOADSORPTION OF ANTI-ACH RECEPTOR ANTIBODIES FROM MYASTHENIC PATIENTS 有权产量从肌肉乙酰胆碱受体重组片段及其对离体免疫吸收抗Ach受体抗体的患者使用重症肌无力
公开(公告)号：EP1509605A2
公开(公告)日：2005-03-02
申请号：EP03712468.2
申请日：2003-04-15
申请人： HELLENIC PASTEUR INSTITUTE , ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES , TZARTOS, Socrates , MAMALAKI, Avgi
IPC分类号： C12N15/12 , C07K14/705 , A61K38/17
CPC分类号： C07K14/70571 , A61K38/00
摘要： A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous systems and obtained in sufficiently folded state appropriate for binding major fractions of anti-AChR antibodies in myasthenia gravis (MG) patients and of immunoadsorbing these antibodies when said polypeptides are used as permanently immobilized on insoluble matrixes. This procedure allows the ex vivo selective elimination of the antibodies against human muscle acetylcholine receptor (AChR), as a replacement and improvement of the non-specific plasmapheresis or Ig apheresis, for the temporary repeated treatment of the disease MG.
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公开(公告)号：EP2769220B8
公开(公告)日：2020-11-18
申请号：EP12772445.8
申请日：2012-08-14
申请人： Tzartos, Socrates
IPC分类号： G01N33/564 , A61K38/17 , C07K14/47 , G01N33/538 , C07K16/28
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公开(公告)号：EP2561358A2
公开(公告)日：2013-02-27
申请号：EP11724450.9
申请日：2011-04-18
发明人： TZARTOS, Socrates , TZARTOS, John , TZARTOU, Elissavet , TRAKAS, Nikolaos , STERGIOU, Christos , ZISIMOPOULOU, Paraskevi
CPC分类号： G01N33/564 , G01N2800/285
摘要： A method of detecting the presence of a target molecule in a biological sample from a subject, wherein the target molecule is capable of binding to a binding molecule, wherein the method comprises the steps of: a) subjecting the biological sample to a purification step to provide an enriched target molecule sample, wherein the purification step comprises: i) contacting binding molecules with the biological sample to enable binding of the target molecules to the binding molecules, and ii) removing target molecules from the binding molecules to provide the enriched target molecule sample; and b) subjecting the enriched target molecule sample to an assay to detect the presence of the target molecule.
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4.发明授权PRODUCTION OF RECOMBINANT FRAGMENTS OF MUSCLE ACETYLCHOLINE RECEPTOR AND THEIR USE FOR EX VIVO IMMUNOADSORPTION OF ANTI-ACH RECEPTOR ANTIBODIES FROM MYASTHENIC PATIENTS 有权产量从肌肉乙酰胆碱受体重组片段及其对离体免疫吸收抗Ach受体抗体的患者使用重症肌无力
公开(公告)号：EP1509605B1
公开(公告)日：2009-09-30
申请号：EP03712468.2
申请日：2003-04-15
申请人： HELLENIC PASTEUR INSTITUTE , ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES , TZARTOS, Socrates , MAMALAKI, Avgi
IPC分类号： C12N15/12 , C07K14/705 , A61K38/17
CPC分类号： C07K14/70571 , A61K38/00
摘要： A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous systems and obtained in sufficiently folded state appropriate for binding major fractions of anti-AChR antibodies in myasthenia gravis (MG) patients and of immunoadsorbing these antibodies when said polypeptides are used as permanently immobilized on insoluble matrixes. This procedure allows the ex vivo selective elimination of the antibodies against human muscle acetylcholine receptor (AChR), as a replacement and improvement of the non-specific plasmapheresis or Ig apheresis, for the temporary repeated treatment of the disease MG.
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