公开(公告)号：EP1620203A2

公开(公告)日：2006-02-01

申请号：EP04750184.6

申请日：2004-04-08

申请人： U.S. Genomics, Inc.

发明人： FUCHS, Martin ,  LARSON, Jonathan

IPC分类号： B01L3/00

CPC分类号： G01N35/00069 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2400/0463 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N15/1475 ,  G01N2015/1006 ,  G01N2015/1413

摘要： A microfluidic device for altering the flow of a carrier fluid containing a polymer, such that, the polymer can be positioned, aligned, or elongated. The device accomplishes these effects by directing the carrier fluid in a laminar flow into obstacles, or other fluids to knowingly alter the path of the carrier fluid streamlines. These streamlines, in turn, apply fluidic drag forces against the polymer to manipulate it into a desired configuration. Other aspects of the device retain a polymer in an aligned or elongated state with crimps which prevent portions of the polymer from coiling. These structures utilize the natural concept of increasing entropy to allow small portions of an aligned or elongated polymer to return to a high entropy, or coiled state, while retaining the majority of the polymer in a low entropy, aligned or elongated state for subsequent analysis or manipulation.

公开(公告)号：EP1436424A2

公开(公告)日：2004-07-14

申请号：EP02773473.0

申请日：2002-09-18

申请人： U.S. Genomics, Inc.

发明人： CHAN, Eugene, Y. ,  FUCHS, Martin ,  GILMANSHIN, Rudolf

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6869 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q2565/629 ,  C12Q2565/102 ,  C12Q2563/107

摘要： The invention provides methods and systems for improved spatial resolution of signal detection, particularly as applied to the analysis of polymers such as biological polymers. The methods and systems comprise differentially tagging polymers in order to increase resolution.

公开(公告)号：EP1786932A2

公开(公告)日：2007-05-23

申请号：EP05810258.3

申请日：2005-08-23

申请人： U.S. Genomics, Inc.

发明人： FUCHS, Martin ,  HARRIS, John ,  MEYER, Ray

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N21/64

CPC分类号： G01N21/6428 ,  C12Q1/6816 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  Y10T436/143333 ,  C12Q2565/102

摘要： A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels.

公开(公告)号：EP1546380A1

公开(公告)日：2005-06-29

申请号：EP03734255.7

申请日：2003-05-28

申请人： U.S. Genomics, Inc.

发明人： ZHAO, Xiaojian ,  RANDALL, Jeffrey, D. ,  KUNDU, Bijit ,  KESTY, Jessica ,  GULLANS, Steve ,  CHAN, Eugene ,  FUCHS, Martin

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6834 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q2565/601 ,  C12Q2521/301 ,  C12Q2563/107 ,  C12Q2565/619 ,  C12Q2565/629 ,  C12Q2535/125 ,  C12Q2565/101

摘要： The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.