公开(公告)号：EP1543155A2

公开(公告)日：2005-06-22

申请号：EP03764783.1

申请日：2003-07-17

申请人： U.S. Genomics, Inc.

发明人： GILMANSHIN, Rudolf

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04 ,  C07H19/00

CPC分类号： B82Y5/00 ,  B82Y10/00 ,  C07K1/1077 ,  C12Q1/6832 ,  C12Q2527/143 ,  C12Q2525/107 ,  C12Q2522/101

摘要： The invention relates to the use of conjugates of nucleic acid tag molecules and nucleic acid binding agents for labeling polymers such as nucleic acid molecules. The nucleic acid binding agents for labeling polymers such as nucleic acid molecules. The nucleic acid binding agents are nucleic acid binding enzymes that bind nucleic acid molecules non-specifically, in some embodiments. The conjugate can be formed by directly or indirectly binding the nucleic acid tag molecules to the nucleic acid binding agents. The invention provides conjugate compositions as well as methods and systems for using the conjugates to label and analyze polymers such as nucleic acid molecules.

公开(公告)号：EP1402245A1

公开(公告)日：2004-03-31

申请号：EP02737289.5

申请日：2002-05-31

申请人： U.S. Genomics, Inc.

发明人： CHAN, Eugene, Y. ,  GLEICH, Lance, C. ,  WELLMAN, Parris, S.

IPC分类号： G01N21/64

CPC分类号： B01L3/502761 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2300/0816 ,  B01L2400/086 ,  C12Q1/6869 ,  G01N1/286 ,  G01N15/1456 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/442 ,  G01N2015/1075 ,  G01N2015/1493 ,  G01N2015/1495 ,  Y10T436/13 ,  Y10T436/143333

摘要： In a method and apparatus for determining the velocity of an elongated polymeric molecule, the molecule (105) is moved relative to one or more detection stations (101,.102, 103). Time correlated detection signals are used to determine velocity, length, and distance between landmarks on the molecule (105).

公开(公告)号：EP1704256A2

公开(公告)日：2006-09-27

申请号：EP05722410.7

申请日：2005-01-13

申请人： U.S. Genomics, Inc.

发明人： GILMANSHIN, Rudolf

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/02 ,  C12N15/11

CPC分类号： G01N33/542

摘要： The invention relates to methods and systems for identifying, quantitating and/or analyzing analytes from samples. The analytes may be organic or inorganic in nature and include but are not limited to pathogens such as viruses.

公开(公告)号：EP1436424A2

公开(公告)日：2004-07-14

申请号：EP02773473.0

申请日：2002-09-18

申请人： U.S. Genomics, Inc.

发明人： CHAN, Eugene, Y. ,  FUCHS, Martin ,  GILMANSHIN, Rudolf

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6869 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q2565/629 ,  C12Q2565/102 ,  C12Q2563/107

摘要： The invention provides methods and systems for improved spatial resolution of signal detection, particularly as applied to the analysis of polymers such as biological polymers. The methods and systems comprise differentially tagging polymers in order to increase resolution.

公开(公告)号：EP1402069A1

公开(公告)日：2004-03-31

申请号：EP02739763.7

申请日：2002-06-10

申请人： U.S. Genomics, Inc.

发明人： WONG, Gordon, G.

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6825 ,  C12Q1/6886 ,  C12Q2525/117 ,  C12Q2521/307 ,  C12Q2521/101

摘要： The invention relates to methods, products and systems for analyzing nucleic acid molecules using sequence specific nick translation. The methods can be used to obtain sequence information about the nucleic acid mulecules and to assess the efficacy of therape utic treatments that affect based on DNA damage induction.

公开(公告)号：EP1586068B1

公开(公告)日：2008-07-30

申请号：EP04704877.2

申请日：2004-01-23

申请人： U.S. Genomics, Inc.

发明人： GILMANSHIN, Rudolf ,  PHILLIPS, Kevin, A. ,  LARSON, Jonathan

IPC分类号： G06F19/00 ,  C12Q1/68

CPC分类号： G01N21/6428 ,  B01J2219/005 ,  B01J2219/00529 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00608 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/06 ,  C40B40/10

摘要： The invention relates to methods and algorithms for processing polymer analysis data. More specifically, the data is analyzed in order to align, orient and discern individual polymer data from a population data set.

公开(公告)号：EP1786932A2

公开(公告)日：2007-05-23

申请号：EP05810258.3

申请日：2005-08-23

申请人： U.S. Genomics, Inc.

发明人： FUCHS, Martin ,  HARRIS, John ,  MEYER, Ray

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N21/64

CPC分类号： G01N21/6428 ,  C12Q1/6816 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  Y10T436/143333 ,  C12Q2565/102

摘要： A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels.

公开(公告)号：EP1725587A2

公开(公告)日：2006-11-29

申请号：EP05732256.2

申请日：2005-03-21

申请人： U.S. Genomics, Inc.

发明人： NALEFSKI, Eric, A. ,  GULLANS, Steven, R.

IPC分类号： C07K16/00 ,  C12P21/08 ,  G01N21/76 ,  G01N33/563

CPC分类号： G01N33/68 ,  G01N33/6845

摘要： The invention relates to compositions and methods for detecting proteins and their interactions with other molecules, including measuring affinity and kinetic constants. The method employs two or more protein-specific probes labeled with detectable labels such as fluorophores that are distinguishable from each other. Binding of the probes to the target protein is detected as temporally coincident signals, such that binding of multiple probes to a single target protein indicates that the protein is present in a sample.

公开(公告)号：EP1546380A1

公开(公告)日：2005-06-29

申请号：EP03734255.7

申请日：2003-05-28

申请人： U.S. Genomics, Inc.

发明人： ZHAO, Xiaojian ,  RANDALL, Jeffrey, D. ,  KUNDU, Bijit ,  KESTY, Jessica ,  GULLANS, Steve ,  CHAN, Eugene ,  FUCHS, Martin

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6834 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q2565/601 ,  C12Q2521/301 ,  C12Q2563/107 ,  C12Q2565/619 ,  C12Q2565/629 ,  C12Q2535/125 ,  C12Q2565/101

摘要： The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

公开(公告)号：EP1586068A1

公开(公告)日：2005-10-19

申请号：EP04704877.2

申请日：2004-01-23

申请人： U.S. Genomics, Inc.

发明人： GILMANSHIN, Rudolf ,  PHILLIPS, Kevin, A. ,  LARSON, Jonathan

IPC分类号： G06F19/00 ,  C12Q1/68

CPC分类号： G01N21/6428 ,  B01J2219/005 ,  B01J2219/00529 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00608 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/06 ,  C40B40/10

摘要： The invention relates to methods and algorithms for processing polymer analysis data. More specifically, the data is analyzed in order to align, orient and discern individual polymer data from a population data set.