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    PROCESS FOR THE PREPARATION OF QUINOLYLPROPENAL
    2.
    发明公开
    PROCESS FOR THE PREPARATION OF QUINOLYLPROPENAL 有权
    VERFAHREN ZUR HERSTELLUNG VON QUINOLYLPROPENAL

    公开(公告)号：EP1251124A4

    公开(公告)日：2004-09-01

    申请号：EP01901538

    申请日：2001-01-24

    申请人： NISSAN CHEMICAL IND LTD

    发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  OKADA NAOKO

    IPC分类号： C07D215/14 ,  C07B61/00

    CPC分类号： C07D215/14

    摘要： 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enal is prepared in a high yield by reducing 3-[2- cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.

    摘要翻译： 3- [2-环丙基-4-（4-氟苯基）-3-喹啉基]丙-2-烯醛通过将3- [2-环丙基-4-（4-氟苯基）-3-喹啉基 ]丙-2-烯腈与阮内镍在甲酸和0.25-1体积份水/每体积份甲酸存在下或在存在甲酸和有机酸的胺盐的条件下进行反应。

    PROCESS FOR PRODUCING BETA-KETONITRILE COMPOUND
    4.
    发明公开
    PROCESS FOR PRODUCING BETA-KETONITRILE COMPOUND 有权
    VERFAHREN ZUR HERSTELLUNG VON BETA-KETONITRILVERBINDUNGEN

    公开(公告)号：EP1352898A4

    公开(公告)日：2005-07-20

    申请号：EP01272314

    申请日：2001-12-25

    申请人： UBE INDUSTRIES

    发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  NAKAMURA AKIRA ,  HARADA TAKASHI

    IPC分类号： C07C253/30 ,  C07C255/17 ,  C07C255/31

    CPC分类号： C07C253/30 ,  C07C2601/02 ,  C07C255/17 ,  C07C255/31

    摘要： A process comprising reacting an aliphatic carboxylic ester compound with acetonitrile in the presence of a metal alkoxide to yield a metal salt of a β-ketonitrile compound, subsequently transferring the salt to an aqueous medium, and neutralizing the solution to obtain the β-Ketonitrile compound in a free state, wherein a water-incompatible organic solvent and water are added to the reaction mixture containing the β-Ketonotrile compound metal salt yielded to transfer the metal salt to the water, the resultant aqueous solution of the β-Ketonitrile compound metal salt is separated from the organic solvent by phase separation or another technique and then neutralized, and the resultant free β- Ketonitrile compound is taken out by extraction with an organic solvent.

    摘要翻译： 在金属醇盐存在下，使脂肪族羧酸酯化合物与乙腈反应，生成β-酮腈化合物的金属盐后，将其转移到水性介质中，中和该溶液，得到β-酮腈化合物 在游离状态下，向含有β-酮化合物金属盐的反应混合物中加入水不相容有机溶剂和水，将所得金属盐转移到水中，得到的β-酮腈化合物金属盐水溶液 通过相分离或其他技术从有机溶剂中分离出来，然后中和，并且通过用有机溶剂萃取而将所得的游离β-乙腈化合物取出。

    PROCESSES FOR PRODUCING ALKYL 3-(4-TETRAHYDROPYRANYL)-3-OXOPROPIONATE COMPOUND AND 4-ACYLTETRAHYDROPYRAN
    6.
    发明公开
    PROCESSES FOR PRODUCING ALKYL 3-(4-TETRAHYDROPYRANYL)-3-OXOPROPIONATE COMPOUND AND 4-ACYLTETRAHYDROPYRAN 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON EINER 3-（4-四氢吡喃基）-3-氧代丙酸4-乙酰基四氢吡喃

    公开(公告)号：EP1700852A4

    公开(公告)日：2009-07-22

    申请号：EP04807296

    申请日：2004-12-17

    申请人： UBE INDUSTRIES

    发明人： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  IWAMOTO KEIJI ,  HARADA TAKASHI

    IPC分类号： C07D309/06 ,  C07B61/00

    CPC分类号： C07D309/06

    摘要： A process for producing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropionate compound represented by the formula (1): (1) (wherein R1 and R2 may be the same or different and each represents a group not participating in the reaction, provided that R1 and R2 may be bonded to each other to form a ring optionally containing a heteroatom therein; and R3 represents a hydrocarbon group), characterized by reacting a 4-acyltetrahydropyran represented by the formula (2): (2) (wherein R1 and R2 have the same meanings as defined above) with a carbonic diester represented by the formula (3): (3) (wherein R3 has the same meaning as defined above, provided that the two R3's may be bonded to each other to form a ring) in the presence of a base. Also provided is a process for producing the 4-acyltetrahydropyran.

    摘要翻译： 一种制备式（1）代表的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：（1）（其中R1和R2可以相同或不同，各自代表不参与反应的基团 （2）表示的4-酰基四氢吡喃的特征在于：（2）（式中，R 1和R 2可以相互结合而形成任选含有杂原子的环，R 3表示烃基） （3）表示的碳酸二酯：（3）（式中，R 3与上述定义相同，条件是两个R 3可以相互键合形成），其中R 1和R 2具有与上述定义相同的含义。 一个环）在一个基地的存在。 还提供了生产4-酰基四氢吡喃的方法。

    PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND
    8.
    发明公开
    PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND 有权
    VERFAHREN ZUR HERSTELLUNG EINER 4-AMINOCHINAZOLINVERBINDUNG

    公开(公告)号：EP1481971A4

    公开(公告)日：2006-03-08

    申请号：EP03703218

    申请日：2003-02-06

    申请人： UBE INDUSTRIES

    发明人： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  ODA HIROYUKI

    IPC分类号： C07D239/86 ,  C07D239/88 ,  C07D239/94

    CPC分类号： C07D239/88 ,  C07D239/94

    摘要： Quinazolin-4-one or a derivative thereof is reacted with a chlorinating agent in a first organic solvent in the presence of an organic base. Subsequently, the reaction product is reacted with an amine compound represented by the formula R5-NH-R6 (R5 and R6 each represents hydrogen or an optionally substituted hydrocarbon group) in the presence of a second organic solvent. Thus, a 4-aminoquinazoline derivative can be obtained.

    摘要翻译： 喹唑啉-4-酮或其衍生物与氯化剂在第一有机溶剂中在有机碱存在下反应。 随后，在第二有机溶剂存在下，使反应产物与式R5-NH-R6表示的胺化合物（R5和R6各自表示氢或任选取代的烃基）反应。 因此，可以获得4-氨基喹唑啉衍生物。