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公开(公告)号：EP3436456A1
公开(公告)日：2019-02-06
申请号：EP17713705.6
申请日：2017-03-31
申请人： UCB Biopharma SPRL , SANOFI
发明人： DE HARO GARCIA, Teresa , DELIGNY, Michaël Louis Robert , HEER, Jag Paul , HORSLEY, Helen Tracey , JADOT, Sophie , KEYAERTS, Jean
IPC分类号： C07D487/04 , C07D487/18 , A61K31/428 , A61K31/4188
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公开(公告)号：EP3356365A1
公开(公告)日：2018-08-08
申请号：EP16777628.5
申请日：2016-09-28
IPC分类号： C07D471/04 , A61K31/519 , A61K31/4375 , A61K31/496 , A61P29/00 , A61P35/00 , A61P31/00 , A61P33/00
CPC分类号： C07D471/04 , A61K2121/00 , A61P29/00 , A61P31/12 , A61P33/06 , A61P35/00 , A61P37/06
摘要： A series of substituted pyrido[3,2-d]pyrimidine and 1,5-naphthyridine derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
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公开(公告)号：EP3356367A1
公开(公告)日：2018-08-08
申请号：EP16770942.7
申请日：2016-09-28
IPC分类号： C07D487/04 , C07D491/107 , C07D491/08 , C07D498/04 , C07D451/06 , A61K31/519 , A61K31/53 , A61P29/00 , A61P35/00 , A61P31/00 , A61P33/00 , A61K31/5377 , A61K31/5386
CPC分类号： C07D487/04 , C07D451/06 , C07D491/08 , C07D491/107 , C07D498/04
摘要： A series of substituted pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a][1,3,5]-triazine derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
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公开(公告)号：EP3157924A1
公开(公告)日：2017-04-26
申请号：EP15728516.4
申请日：2015-06-11
发明人： HORSLEY, Helen Tracey , HUANG, Qiuya , NEUSS, Judi Charlotte , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61P29/00
CPC分类号： C07D487/04 , A61K31/495 , A61K31/53 , C07D403/04
摘要： A series of fused bicyclic heteroaromatic derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
摘要翻译： 如本文所定义的一系列式（I）的稠合双环杂芳族衍生物是磷脂酰肌醇-4-激酶IIIβ（PI4KIIIβ）活性的选择性抑制剂，有益于治疗和/或预防各种人类疾病，包括炎性，自身免疫 和肿瘤疾病; 病毒性疾病和疟疾; 和器官和细胞移植排斥反应。
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公开(公告)号：EP2935269A1
公开(公告)日：2015-10-28
申请号：EP13814962.0
申请日：2013-12-20
发明人： FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , HORSLEY, Helen Tracey , HUANG, Qiuya , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D471/04
摘要： A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
摘要翻译： 在4-位被二氮杂单环，桥连双环或螺环部分取代的一系列吡唑并[3,4-d]嘧啶衍生物有益于治疗和/或预防各种人类疾病，包括炎性，自身免疫 和肿瘤疾病; 病毒性疾病和疟疾; 和器官和细胞移植排斥反应。
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公开(公告)号：EP2935269B1
公开(公告)日：2018-04-11
申请号：EP13814962.0
申请日：2013-12-20
发明人： FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , HORSLEY, Helen Tracey , HUANG, Qiuya , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D471/04
摘要： A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
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公开(公告)号：EP3386984A1
公开(公告)日：2018-10-17
申请号：EP16808633.8
申请日：2016-12-08
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04 , A61P29/00 , A61P31/12 , A61P33/06 , A61P35/00 , A61P37/06 , C07D519/00
摘要： A series of 1,2,6,7,9,9a-hexahydropyrazino[1,2-d][1,2,4]triazin-4-one derivatives, substituted in the 8-position by an optionally substituted fused bicyclic heteroaromatic group, and in the 3-position by a range of functional groups, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
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公开(公告)号：EP2872508B1
公开(公告)日：2018-08-29
申请号：EP13739376.5
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： BENTLEY, Jonathan Mark , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , CAIN, Thomas Paul , CHOVATIA, Praful Tulshi , FOLEY, Anne Marie , GALLIMORE, Ellen Olivia , GLEAVE, Laura Jane , HEIFETZ, Alexander , HORSLEY, Helen Tracey , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , JOHNSON, James Andrew , JOHNSTONE, Craig , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LEIGH, Deborah , LOWE, Martin Alexander , MADDEN, James , PORTER, John Robert , QUINCEY, Joanna Rachel , REED, Laura Claire , REUBERSON, James Thomas , RICHARDSON, Anthony John , RICHARDSON, Sarah Emily , SELBY, Matthew Duncan , SHAW, Michael Alan , ZHU, Zhaoning
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP2872508A1
公开(公告)日：2015-05-20
申请号：EP13739376.5
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： BENTLEY, Jonathan Mark , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , CAIN, Thomas Paul , CHOVATIA, Praful Tulshi , FOLEY, Anne Marie , GALLIMORE, Ellen Olivia , GLEAVE, Laura Jane , HEIFETZ, Alexander , HORSLEY, Helen Tracey , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , JOHNSON, James Andrew , JOHNSTONE, Craig , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LEIGH, Deborah , LOWE, Martin Alexander , MADDEN, James , PORTER, John Robert , QUINCEY, Joanna Rachel , REED, Laura Claire , REUBERSON, James Thomas , RICHARDSON, Anthony John , RICHARDSON, Sarah Emily , SELBY, Matthew Duncan , SHAW, Michael Alan , ZHU, Zhaoning
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列式（I）的咪唑并[1,2-a]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。
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