公开(公告)号：EP2872508B1

公开(公告)日：2018-08-29

申请号：EP13739376.5

申请日：2013-07-05

申请人： UCB Biopharma SPRL

发明人： BENTLEY, Jonathan Mark ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  CAIN, Thomas Paul ,  CHOVATIA, Praful Tulshi ,  FOLEY, Anne Marie ,  GALLIMORE, Ellen Olivia ,  GLEAVE, Laura Jane ,  HEIFETZ, Alexander ,  HORSLEY, Helen Tracey ,  HUTCHINGS, Martin Clive ,  JACKSON, Victoria Elizabeth ,  JOHNSON, James Andrew ,  JOHNSTONE, Craig ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  LEIGH, Deborah ,  LOWE, Martin Alexander ,  MADDEN, James ,  PORTER, John Robert ,  QUINCEY, Joanna Rachel ,  REED, Laura Claire ,  REUBERSON, James Thomas ,  RICHARDSON, Anthony John ,  RICHARDSON, Sarah Emily ,  SELBY, Matthew Duncan ,  SHAW, Michael Alan ,  ZHU, Zhaoning

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/5513 ,  A61K31/554 ,  C07D491/107 ,  C07D519/00

摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：EP2872508A1

公开(公告)日：2015-05-20

申请号：EP13739376.5

申请日：2013-07-05

申请人： UCB Biopharma SPRL

发明人： BENTLEY, Jonathan Mark ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  CAIN, Thomas Paul ,  CHOVATIA, Praful Tulshi ,  FOLEY, Anne Marie ,  GALLIMORE, Ellen Olivia ,  GLEAVE, Laura Jane ,  HEIFETZ, Alexander ,  HORSLEY, Helen Tracey ,  HUTCHINGS, Martin Clive ,  JACKSON, Victoria Elizabeth ,  JOHNSON, James Andrew ,  JOHNSTONE, Craig ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  LEIGH, Deborah ,  LOWE, Martin Alexander ,  MADDEN, James ,  PORTER, John Robert ,  QUINCEY, Joanna Rachel ,  REED, Laura Claire ,  REUBERSON, James Thomas ,  RICHARDSON, Anthony John ,  RICHARDSON, Sarah Emily ,  SELBY, Matthew Duncan ,  SHAW, Michael Alan ,  ZHU, Zhaoning

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/5513 ,  A61K31/554 ,  C07D491/107 ,  C07D519/00

摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列式（I）的咪唑并[1,2-a]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。