公开(公告)号：EP2858983A1

公开(公告)日：2015-04-15

申请号：EP13727932.9

申请日：2013-06-11

申请人： UCB Biopharma SPRL

发明人： BROOKINGS, Daniel, Christopher ,  CALMIANO, Mark, Daniel ,  GALLIMORE, Ellen, Olivia ,  HORSLEY, Helen, Tracey ,  HUTCHINGS, Martin, Clive ,  JOHNSON, James, Andrew ,  KROEPLIEN, Boris ,  LECOMTE, Fabien, Claude ,  LOWE, Martin, Alexander ,  NORMAN, Timothy, John ,  PORTER, John, Robert ,  QUINCEY, Joanna, Rachel ,  REUBERSON, James, Thomas ,  SELBY, Matthew, Duncan ,  SHAW, Michael, Alan ,  ZHU, Zhaoning ,  FOLEY, Anne Marie

IPC分类号： C07D401/04 ,  C07D235/12 ,  A61K31/4427 ,  A61P29/00

CPC分类号： C07D235/12 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D491/107

摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：EP2858983B1

公开(公告)日：2018-04-18

申请号：EP13727932.9

申请日：2013-06-11

申请人： UCB Biopharma SPRL

发明人： BROOKINGS, Daniel, Christopher ,  CALMIANO, Mark, Daniel ,  GALLIMORE, Ellen, Olivia ,  HORSLEY, Helen, Tracey ,  HUTCHINGS, Martin, Clive ,  JOHNSON, James, Andrew ,  KROEPLIEN, Boris ,  LECOMTE, Fabien, Claude ,  LOWE, Martin, Alexander ,  NORMAN, Timothy, John ,  PORTER, John, Robert ,  QUINCEY, Joanna, Rachel ,  REUBERSON, James, Thomas ,  SELBY, Matthew, Duncan ,  SHAW, Michael, Alan ,  ZHU, Zhaoning ,  FOLEY, Anne Marie

IPC分类号： C07D401/04 ,  C07D235/12 ,  A61K31/4427 ,  A61P29/00

CPC分类号： C07D235/12 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D491/107

摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.