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    MULTIVALENT ANTIBODIES
    1.
    发明公开
    MULTIVALENT ANTIBODIES 有权
    三价抗体

    公开(公告)号：EP2523972A1

    公开(公告)日：2012-11-21

    申请号：EP11700101.6

    申请日：2011-01-12

    申请人： UCB Pharma S.A.

    发明人： ADAMS, Ralph ,  DAVE, Emma

    IPC分类号： C07K16/00

    CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/18 ,  C07K16/241 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/62 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/92

    摘要： The present invention provides a recombinant antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a C
    H1 constant region fragment located between a first and second variable domain, and a third variable domain linked directly or indirectly to the first or second variable domain, with the proviso that the heavy chain only contains one C
    H1 and only contains three variable domains, and a light chain comprising at least a C
    L domain located between a first and second variable domain, and a third variable domain linked directly or indirectly to the first or second variable domain, with the proviso that the light chain only contains one C
    L domain and only contains three variable domains, and wherein said heavy and light chains are aligned to provide a first binding site formed by the first variable domains in the light and heavy chain, a second binding site formed by the second variable domains in the light and heavy chain, and a third binding site formed by the third variable domains in the light and heavy chain.

    MULTIVALENT ANTIBODIES
    2.
    发明公开
    MULTIVALENT ANTIBODIES 有权
    多抗体

    公开(公告)号：EP2475682A1

    公开(公告)日：2012-07-18

    申请号：EP10754975.0

    申请日：2010-09-10

    申请人： UCB Pharma S.A.

    发明人： ADAMS, Ralph ,  DAVE, Emma ,  HUMPHREYS, David, Paul

    IPC分类号： C07K16/00 ,  C07K16/46

    CPC分类号： C07K16/2878 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  C07K16/2875 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/624 ,  C07K2317/92

    摘要： The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    摘要翻译： 本发明提供了多价抗体或其重链/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 具有选自CH 2，CH 3及其组合的至少一个结构域，条件是重链含有不超过一个CH 1结构域并且仅包含两个可变结构域，并且轻链包含位于两个可变结构域之间的恒定区片段， 不是同源对，其中所述重链和轻链排列成提供由第一同源对可变域形成的第一结合位点和由第二同源对可变域形成的第二结合位点。

    MULTI-SPECIFIC ANTIBODY CONSTRUCTS
    4.
    发明公开
    MULTI-SPECIFIC ANTIBODY CONSTRUCTS 审中-公开
    多特异性抗体构建体

    公开(公告)号：EP3161008A1

    公开(公告)日：2017-05-03

    申请号：EP15733415.2

    申请日：2015-06-25

    申请人： UCB Pharma, S.A.

    发明人： BHATTA, Pallavi ,  DAVE, Emma ,  HEYWOOD, Sam Philip ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/46

    CPC分类号： C07K16/468 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/94 ,  C07K2319/00

    摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-CH2-CH3-X-(V1)p; and b) a polypeptide chain of formula (II): VL-CL-Y-(V2)q and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multi-specific antibody molecule of the present disclosure from a host cell.

    摘要翻译： 本发明涉及多特异性抗体分子，其包含或由以下组成：a）式（I）的多肽链：VH-CH 1 -CH 2 -CH 3 -X-（V 1）p; 和b）式（II）的多肽链：VL-CL-Y-（V2）q和包含例如用于治疗的药物制剂。 本公开内容还提供了编码所述多特异性抗体分子的多核苷酸序列，包含所述多核苷酸的载体和包含所述载体和/或多核苷酸序列的宿主细胞。 提供了从宿主细胞表达本公开内容的多特异性抗体分子的方法。