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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    1.
    发明公开
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权
    BINDUNGSFRAGMENTEN DAVON的ALBUMINBINDENDEANTIKÖRPER

    公开(公告)号：EP2776466A1

    公开(公告)日：2014-09-17

    申请号：EP12801467.7

    申请日：2012-11-09

    申请人： UCB Pharma, S.A.

    发明人： ADAMS, Ralph ,  BHATTA, Pallavi ,  HEYWOOD, Sam Phillip ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/18 ,  C07K16/46 ,  C07K16/28

    CPC分类号： C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    摘要： A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    摘要翻译： 1.一种血清白蛋白结合抗体或其片段，其包含具有SEQ ID NO：1或SEQ ID NO：2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO：3中给出的序列的轻链可变区或 SEQ ID NO：4，特别包括具有SEQ ID NO：1和SEQ ID NO：3中给出的序列的重链可变结构域和轻链可变结构域或重链可变结构域和具有 SEQ ID NO：2和SEQ ID NO：4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸，包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物，其包含使用其中任何一种的抗体或片段和治疗剂。

    MULTIVALENT ANTIBODIES
    5.
    发明公开
    MULTIVALENT ANTIBODIES 有权
    三价抗体

    公开(公告)号：EP2523972A1

    公开(公告)日：2012-11-21

    申请号：EP11700101.6

    申请日：2011-01-12

    申请人： UCB Pharma S.A.

    发明人： ADAMS, Ralph ,  DAVE, Emma

    IPC分类号： C07K16/00

    CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/18 ,  C07K16/241 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/62 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/92

    摘要： The present invention provides a recombinant antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a C
    H1 constant region fragment located between a first and second variable domain, and a third variable domain linked directly or indirectly to the first or second variable domain, with the proviso that the heavy chain only contains one C
    H1 and only contains three variable domains, and a light chain comprising at least a C
    L domain located between a first and second variable domain, and a third variable domain linked directly or indirectly to the first or second variable domain, with the proviso that the light chain only contains one C
    L domain and only contains three variable domains, and wherein said heavy and light chains are aligned to provide a first binding site formed by the first variable domains in the light and heavy chain, a second binding site formed by the second variable domains in the light and heavy chain, and a third binding site formed by the third variable domains in the light and heavy chain.