摘要:
The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要:
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
摘要翻译:1.一种血清白蛋白结合抗体或其片段,其包含具有SEQ ID NO:1或SEQ ID NO:2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO:3中给出的序列的轻链可变区或 SEQ ID NO:4,特别包括具有SEQ ID NO:1和SEQ ID NO:3中给出的序列的重链可变结构域和轻链可变结构域或重链可变结构域和具有 SEQ ID NO:2和SEQ ID NO:4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸,包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物,其包含使用其中任何一种的抗体或片段和治疗剂。