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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    2.
    发明公开
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权
    BINDUNGSFRAGMENTEN DAVON的ALBUMINBINDENDEANTIKÖRPER

    公开(公告)号：EP2776466A1

    公开(公告)日：2014-09-17

    申请号：EP12801467.7

    申请日：2012-11-09

    申请人： UCB Pharma, S.A.

    发明人： ADAMS, Ralph ,  BHATTA, Pallavi ,  HEYWOOD, Sam Phillip ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/18 ,  C07K16/46 ,  C07K16/28

    CPC分类号： C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    摘要： A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    摘要翻译： 1.一种血清白蛋白结合抗体或其片段，其包含具有SEQ ID NO：1或SEQ ID NO：2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO：3中给出的序列的轻链可变区或 SEQ ID NO：4，特别包括具有SEQ ID NO：1和SEQ ID NO：3中给出的序列的重链可变结构域和轻链可变结构域或重链可变结构域和具有 SEQ ID NO：2和SEQ ID NO：4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸，包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物，其包含使用其中任何一种的抗体或片段和治疗剂。

    MULTI-SPECIFIC ANTIBODY CONSTRUCTS
    3.
    发明公开
    MULTI-SPECIFIC ANTIBODY CONSTRUCTS 审中-公开
    多特异性抗体构建体

    公开(公告)号：EP3161008A1

    公开(公告)日：2017-05-03

    申请号：EP15733415.2

    申请日：2015-06-25

    申请人： UCB Pharma, S.A.

    发明人： BHATTA, Pallavi ,  DAVE, Emma ,  HEYWOOD, Sam Philip ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/46

    CPC分类号： C07K16/468 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/94 ,  C07K2319/00

    摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-CH2-CH3-X-(V1)p; and b) a polypeptide chain of formula (II): VL-CL-Y-(V2)q and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multi-specific antibody molecule of the present disclosure from a host cell.

    摘要翻译： 本发明涉及多特异性抗体分子，其包含或由以下组成：a）式（I）的多肽链：VH-CH 1 -CH 2 -CH 3 -X-（V 1）p; 和b）式（II）的多肽链：VL-CL-Y-（V2）q和包含例如用于治疗的药物制剂。 本公开内容还提供了编码所述多特异性抗体分子的多核苷酸序列，包含所述多核苷酸的载体和包含所述载体和/或多核苷酸序列的宿主细胞。 提供了从宿主细胞表达本公开内容的多特异性抗体分子的方法。