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公开(公告)号：EP3517110A1
公开(公告)日：2019-07-31
申请号：EP19158338.4
申请日：2010-06-08
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P29/00
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-omithine phenylacetate.
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公开(公告)号：EP2440200B1
公开(公告)日：2014-08-27
申请号：EP10786721.0
申请日：2010-06-08
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P9/12 , A61P1/16
CPC分类号： A61K31/19 , A61K31/192 , A61K31/195
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.
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公开(公告)号：EP2440200B8
公开(公告)日：2014-10-15
申请号：EP10786721.0
申请日：2010-06-08
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P9/12 , A61P1/16
CPC分类号： A61K31/19 , A61K31/192 , A61K31/195
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.
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4.发明公开
公开(公告)号：EP2440200A2
公开(公告)日：2012-04-18
申请号：EP10786721.0
申请日：2010-06-08
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P9/12 , A61P1/16
CPC分类号： A61K31/19 , A61K31/192 , A61K31/195
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.
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公开(公告)号：EP3263100A1
公开(公告)日：2018-01-03
申请号：EP17185173.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46 , C07C57/32
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
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公开(公告)号：EP3263100B1
公开(公告)日：2020-04-01
申请号：EP17185173.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46 , C07C57/32
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公开(公告)号：EP2413924A1
公开(公告)日：2012-02-08
申请号：EP10759442.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
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公开(公告)号：EP4101838A1
公开(公告)日：2022-12-14
申请号：EP22185562.0
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： C07C227/18 , C07C227/42 , C07C229/26 , C07C51/41 , C07C51/43 , C07C57/32
摘要： A process for making L-ornithine phenylacetate, comprising:
forming a solution of L-ornithine, wherein the solution comprises water;
adding a pH modifier to the solution;
adding phenylacetic acid to the solution ; and
isolating L-ornithine phenylacetate from the solution.-
公开(公告)号：EP3686183A1
公开(公告)日：2020-07-29
申请号：EP20161306.4
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： C07C229/26 , A61K31/198 , A61P1/16 , A61K31/192 , C07C57/46 , C07C57/32
摘要： Disclosed herein are crystalline forms of L-omithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
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公开(公告)号：EP2413924B1
公开(公告)日：2017-09-27
申请号：EP10759442.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46 , C07C57/32
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
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