公开(公告)号：EP2440200B8

公开(公告)日：2014-10-15

申请号：EP10786721.0

申请日：2010-06-08

申请人： UCL Business PLC ,  Ocera Therapeutics, Inc.

发明人： JALAN, Rajiv ,  ANDERSON, Keith

IPC分类号： A61K31/195 ,  A61K31/19 ,  A61K31/192 ,  A61P9/12 ,  A61P1/16

CPC分类号： A61K31/19 ,  A61K31/192 ,  A61K31/195

摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.

公开(公告)号：EP2440200A2

公开(公告)日：2012-04-18

申请号：EP10786721.0

申请日：2010-06-08

申请人： UCL Business PLC ,  Ocera Therapeutics Inc.

发明人： JALAN, Rajiv ,  ANDERSON, Keith

IPC分类号： A61K31/195 ,  A61K31/19 ,  A61K31/192 ,  A61P9/12 ,  A61P1/16

CPC分类号： A61K31/19 ,  A61K31/192 ,  A61K31/195

摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.

公开(公告)号：EP3517110A1

公开(公告)日：2019-07-31

申请号：EP19158338.4

申请日：2010-06-08

申请人： UCL Business PLC ,  Ocera Therapeutics, Inc.

发明人： JALAN, Rajiv ,  ANDERSON, Keith

IPC分类号： A61K31/195 ,  A61K31/19 ,  A61K31/192 ,  A61P29/00

摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-omithine phenylacetate.

公开(公告)号：EP2440200B1

公开(公告)日：2014-08-27

申请号：EP10786721.0

申请日：2010-06-08

申请人： UCL Business PLC ,  Ocera Therapeutics Inc.

发明人： JALAN, Rajiv ,  ANDERSON, Keith

IPC分类号： A61K31/195 ,  A61K31/19 ,  A61K31/192 ,  A61P9/12 ,  A61P1/16

CPC分类号： A61K31/19 ,  A61K31/192 ,  A61K31/195

摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.

公开(公告)号：EP1824563B1

公开(公告)日：2010-02-10

申请号：EP05808837.8

申请日：2005-11-28

申请人： UCL Business PLC

发明人： JALAN, Rajiv ,  JALAN, Kamal, Nayan

IPC分类号： A61P1/16 ,  A61K31/192 ,  A61K31/198

CPC分类号： A61K31/198 ,  A61K31/192 ,  A61K2300/00

公开(公告)号：EP3223829A1

公开(公告)日：2017-10-04

申请号：EP15864248.8

申请日：2015-11-23

申请人： UCL Business Plc.

发明人： JALAN, Rajiv ,  ANDREOLA, Fausto ,  MOOKERJEE, Rajeshwar Prosad ,  DE CHIARA, Francesco ,  ROMBOUTS, Krista ,  THOMSEN, Karen Louise

IPC分类号： A61K33/06 ,  A61K31/192 ,  A61K31/198 ,  A61K31/195 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/437 ,  A61P43/00 ,  A61P1/10

CPC分类号： A61K31/216 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/192 ,  A61K31/198 ,  A61K31/437 ,  A61K31/7004 ,  A61K31/7016 ,  A61K33/42 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein are methods of preventing, treating, and delaying the onset or progression of diseases associated with hepatic stellate cells (HSCs), such as non-alcoholic fatty liver disease (NAFLD), fibrosis, and liver cancer, using ammonia-lowering therapies.

摘要翻译： 本文公开了使用降氨治疗预防，治疗和延缓与肝星状细胞（HSC）相关的疾病（例如非酒精性脂肪肝病（NAFLD），纤维化和肝癌）的发作或进展的方法。

公开(公告)号：EP2069781A1

公开(公告)日：2009-06-17

申请号：EP07824351.6

申请日：2007-10-29

申请人： UCL Business PLC

发明人： JALAN, Rajiv ,  MOOKERJEE, Rajeshwar, P. ,  STADLBAUER, Vanessa ,  DAVIES, Nathan

IPC分类号： G01N33/50 ,  G01N33/579 ,  A61K35/00

CPC分类号： G01N33/6893 ,  A61B5/412 ,  A61B5/4244 ,  A61B5/7275 ,  G01N2333/195 ,  G01N2800/52 ,  G06F19/00

摘要： A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.

公开(公告)号：EP3265086A1

公开(公告)日：2018-01-10

申请号：EP16707535.7

申请日：2016-02-25

申请人： UCL Business PLC

发明人： JALAN, Rajiv ,  ANDREOLA, Fausto ,  DI CHIARA, Francesco

IPC分类号： A61K31/4412 ,  A61K31/4704 ,  A61P35/00

CPC分类号： A61K31/4706 ,  A61K31/44 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to the treatment of liver cancer, and provides novel pharmaceutical formulations and novel treatment regimes for this condition.

公开(公告)号：EP2069781B1

公开(公告)日：2015-12-23

申请号：EP07824351.6

申请日：2007-10-29

申请人： UCL Business PLC

发明人： JALAN, Rajiv ,  MOOKERJEE, Rajeshwar, P. ,  STADLBAUER, Vanessa ,  DAVIES, Nathan

IPC分类号： A61B5/00 ,  G01N33/68

CPC分类号： G01N33/6893 ,  A61B5/412 ,  A61B5/4244 ,  A61B5/7275 ,  G01N2333/195 ,  G01N2800/52 ,  G06F19/00

摘要： A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.

公开(公告)号：EP2825181A1

公开(公告)日：2015-01-21

申请号：EP13711116.7

申请日：2013-03-15

申请人： UCL Business Plc.

发明人： HOWELL, Carol Angela ,  MIKHALOVSKY, Sergey Victorovich ,  SANDEMAN, Susan Rachel ,  JALAN, Rajiv ,  MACNAUGHTAN, Jane

IPC分类号： A61K33/44 ,  A61K9/16

摘要： The invention provides porous carbon particles for use in the treatment or prevention of liver disease, wherein at least 20% of the total pore volume is made up of pores having a mean diameter of from 2 to 200 nm and/or wherein the particles comprise micropores of diameter 2 nm or less and small macropores of diameter 50 nm to 500 nm, but substantially no mesopores of diameter greater than 2 nm and less than 50 nm, and substantially no large macropores of diameter greater than 500 nm.

摘要翻译： 本发明提供了多孔碳颗粒用于治疗或预防肝病的用途，worin的总孔体积的至少20％由具有2至200纳米的平均直径的孔和/或worin颗粒包含微孔 直径2nm或更小和直径为50nm至500nm的大孔小，但基本上没有直径的孔大于2nm且小于50纳米，直径大于500nm的基本上没有大孔。