公开(公告)号：EP1509209A1

公开(公告)日：2005-03-02

申请号：EP03729092.1

申请日：2003-05-22

申请人： UMD, Inc.

发明人： PAULETTI, Giovanni, M. ,  LIU, James, H. ,  RITSCHELL, Wolfgang, A.

IPC分类号： A61K9/70 ,  A61K9/48

CPC分类号： A61K31/663 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/02 ,  A61K31/192 ,  A61K31/196 ,  A61K31/277 ,  A61K31/337 ,  A61K31/405 ,  A61K31/407 ,  A61K31/5415 ,  A61K31/616 ,  A61K38/00 ,  A61K45/06 ,  A61K47/10

摘要： Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a no-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long-term preservation of cell or embryos.