公开(公告)号：EP1948103A2

公开(公告)日：2008-07-30

申请号：EP06824976.2

申请日：2006-09-15

申请人： UMD, Inc.

发明人： PAULETTI, Giovanni, M.

IPC分类号： A61F6/06 ,  A61F13/00

CPC分类号： A61K36/28 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/02 ,  A61K9/122 ,  A61K9/7007 ,  A61K36/185 ,  A61K36/324 ,  A61K36/54 ,  A61K36/67 ,  A61K36/71 ,  A61K36/752 ,  A61K36/77 ,  A61K36/82 ,  A61K36/84 ,  A61K36/8962 ,  A61K36/906 ,  A61K36/9068

摘要： A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.

公开(公告)号：EP1861058A1

公开(公告)日：2007-12-05

申请号：EP06735541.2

申请日：2006-02-17

申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  UMD, Inc.

发明人： HEUER, Daniel, J. ,  RAJALA, Gregory, J. ,  DAMICO, Joyce, ,  BURNETT, Steven, R.

IPC分类号： A61F13/26 ,  A61F13/28 ,  A61M31/00

CPC分类号： A61F13/26 ,  A61F13/2051

摘要： A delivery device is provided including a first member having an interior surface, a receiving end, and an insertion end, wherein the insertion end is open; a tampon body positioned within the first member, wherein the tampon body has a proximal tampon body end and a distal tampon body end; and a second member slidably coupled to the interior surface of the first member at the receiving end. The device also includes a dosage form, wherein the dosage form is coupled to the distal tampon body end; and a protective tube including an open attachment end, an open protective tube second end opposite the attachment end, and a protective tube inner surface including an engagement mechanism enabling the protective tube to be coupled to the receiving end of the first member at the attachment end of the protective tube.

公开(公告)号：EP1776071A2

公开(公告)日：2007-04-25

申请号：EP05791044.0

申请日：2005-07-12

申请人： UMD, Inc.

发明人： WILSON, Michelle ,  DESAI, Kishorkumar, J. ,  PAULETTI, Giovanni, M. ,  ANTOON, Mitchell, K., Jr. ,  CLENDENING, Chris, E.

IPC分类号： A61F6/06 ,  A61F6/14 ,  A61F13/02 ,  A61K9/20 ,  A61K9/48

CPC分类号： A61F6/06 ,  A61F6/08 ,  A61F13/2051 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/02 ,  A61K9/122 ,  A61K9/7007

摘要： A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises -a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.

摘要翻译： 一种阴道装置用于递送一种抗偏头痛或抗恶心药物的子宫和/或通过阴道粘膜的一般循环。 该装置至少部分地涂覆有一种或流体不可渗透的材料的若干层形成帽，薄膜，泡沫，具有粘膜粘附组合物，包含抗偏头痛或抗恶心药物掺入箔或带材。

公开(公告)号：EP1771133A1

公开(公告)日：2007-04-11

申请号：EP05770740.8

申请日：2005-07-11

申请人： UMD, Inc.

发明人： PAULETTI, Giovanni, M. ,  WILSON, Michelle ,  SODERSTROM, Richard ,  DESAI, Kishorkumar, J. ,  RITSCHEL, Wolfgang, A.

IPC分类号： A61F6/06 ,  A61F13/02 ,  A61F6/14

CPC分类号： A61F6/06 ,  A61F6/08 ,  A61F13/2051 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/02 ,  A61K9/122 ,  A61K9/7007

摘要： A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.

摘要翻译： 一种阴道装置用于递送一种抗偏头痛或抗恶心药物的子宫和/或通过阴道粘膜的一般循环。 该装置至少部分地涂覆有一种或流体不可渗透的材料的若干层形成帽，薄膜，泡沫，具有粘膜粘附组合物，包含抗偏头痛或抗恶心药物掺入箔或带材。

公开(公告)号：EP1509209A1

公开(公告)日：2005-03-02

申请号：EP03729092.1

申请日：2003-05-22

申请人： UMD, Inc.

发明人： PAULETTI, Giovanni, M. ,  LIU, James, H. ,  RITSCHELL, Wolfgang, A.

IPC分类号： A61K9/70 ,  A61K9/48

CPC分类号： A61K31/663 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/02 ,  A61K31/192 ,  A61K31/196 ,  A61K31/277 ,  A61K31/337 ,  A61K31/405 ,  A61K31/407 ,  A61K31/5415 ,  A61K31/616 ,  A61K38/00 ,  A61K45/06 ,  A61K47/10

摘要： Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a no-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long-term preservation of cell or embryos.

公开(公告)号：EP1861058B1

公开(公告)日：2009-10-14

申请号：EP06735541.2

申请日：2006-02-17

申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  UMD, Inc.

发明人： HEUER, Daniel, J. ,  RAJALA, Gregory, J. ,  DAMICO, Joyce, ,  BURNETT, Steven, R.

IPC分类号： A61F13/26 ,  A61F13/28 ,  A61M31/00

CPC分类号： A61F13/26 ,  A61F13/2051

摘要： A delivery device is provided including a first member having an interior surface, a receiving end, and an insertion end, wherein the insertion end is open; a tampon body positioned within the first member, wherein the tampon body has a proximal tampon body end and a distal tampon body end; and a second member slidably coupled to the interior surface of the first member at the receiving end. The device also includes a dosage form, wherein the dosage form is coupled to the distal tampon body end; and a protective tube including an open attachment end, an open protective tube second end opposite the attachment end, and a protective tube inner surface including an engagement mechanism enabling the protective tube to be coupled to the receiving end of the first member at the attachment end of the protective tube.

公开(公告)号：EP1301150A4

公开(公告)日：2004-08-11

申请号：EP01959766

申请日：2001-06-25

申请人： UMD INC

发明人： D AUGUSTINE MERIDA A ,  LIU JAMES H ,  HARRISON DONALD C

IPC分类号： A61M31/00 ,  A61F6/08 ,  A61F13/20 ,  A61K9/00 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/14 ,  A61K9/20 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/43 ,  A61K31/496 ,  A61K31/513 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7072 ,  A61K47/10 ,  A61K47/14 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/48 ,  A61P15/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P31/00

CPC分类号： A61F6/08 ,  A61F13/2051 ,  A61K9/0034 ,  A61K9/0036

公开(公告)号：EP1311213A1

公开(公告)日：2003-05-21

申请号：EP01957150.4

申请日：2001-07-12

申请人： UMD, Inc.

发明人： HARRISON, Donald, C. ,  LIU, James, H.

IPC分类号： A61F13/00 ,  A61F6/06 ,  A61F13/02

CPC分类号： A61K9/0036 ,  A61F6/08 ,  A61K9/0034 ,  A61K9/02

摘要： Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.

公开(公告)号：EP1301150A1

公开(公告)日：2003-04-16

申请号：EP01959766.5

申请日：2001-06-25

申请人： UMD, Inc.

发明人： D'AUGUSTINE, Merida, A. ,  LIU, James, H. ,  HARRISON, Donald, C.

IPC分类号： A61F6/06 ,  A61F13/02 ,  A61F13/00 ,  A61L15/16

CPC分类号： A61F6/08 ,  A61F13/2051 ,  A61K9/0034 ,  A61K9/0036

摘要： Devices, methods, and compositions for treating vaginal fungal, bacterial, viral and parasitic infections by intravaginal or transvaginal administration of therapeutic and/or palliative antifungal, antibacterial, antiviral or parasiticidal drugs to the vagina or to the uterus.

公开(公告)号：EP1556001A2

公开(公告)日：2005-07-27

申请号：EP03778010.3

申请日：2003-10-31

申请人： UMD, Inc.

发明人： PAULETTI, Giovanni, M. ,  DESAI, Kishorkumar, J. ,  ROWETON, Susan, L. ,  HARRISON, Donald, C. ,  SANDERS, Lynda, M.

IPC分类号： A61K9/00

CPC分类号： A61K45/06 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/02 ,  A61K9/12 ,  A61K9/7007 ,  A61K31/192 ,  A61K31/196 ,  A61K31/277 ,  A61K31/337 ,  A61K31/405 ,  A61K31/407 ,  A61K31/5415 ,  A61K31/616 ,  A61K31/663 ,  A61K38/00 ,  A61L15/425 ,  A61L15/44 ,  A61L26/0066 ,  A61L26/0085 ,  A61L2300/41

摘要： Polymer foams and films for delivery of therapeutic agents to and through nasal, oral or vaginal mucosa and cornified or non-cornified epithelium of labia and scrotum. Polymer foams or absorbable or non-absorbable films containing a therapeutic agent incorporated therein wherein said agent is released from said foams or films upon placement of said foam or film on the surface epithelium of nasal, oral, or vaginal labia or scrotum. The foam or the film has a controllable rate of gelling, swelling and degradation and is preformed into a device or is applied as a coating to a surface of a more complex drug delivery system.