公开(公告)号：EP1928850A4

公开(公告)日：2009-06-17

申请号：EP06801887

申请日：2006-08-17

申请人： UNIV COLUMBIA

发明人： MARKS ANDREW ROBERT ,  LANDRY DONALD W ,  DENG SHIXIAN ,  CHENG ZHEN ZHUANG ,  LEHNART STEPHAN E

IPC分类号： A61K31/553 ,  C07D281/02

CPC分类号： C07D281/10 ,  C07D417/12 ,  C07D417/14

公开(公告)号：EP2509590A4

公开(公告)日：2013-05-29

申请号：EP10836767

申请日：2010-12-10

申请人： UNIV COLUMBIA

发明人： FENG YAN ,  FA MAURO ,  ARANCIO OTTAVIO ,  DENG SHIXIAN ,  LANDRY DONALD W ,  FRANCIS YITSHAK

IPC分类号： A61K31/27 ,  C07C235/64 ,  C07C311/29 ,  C07C323/31 ,  C07C323/62 ,  C07D213/75 ,  C07D213/82 ,  C07D233/90 ,  C07D333/38

CPC分类号： A61K31/27 ,  C07C235/64 ,  C07C323/42 ,  C07C323/44 ,  C07C323/62 ,  C07C323/67 ,  C07D213/75 ,  C07D213/82 ,  C07D239/52 ,  C07D333/38

摘要： The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

公开(公告)号：EP2945934A4

公开(公告)日：2016-06-15

申请号：EP14741139

申请日：2014-01-14

申请人： UNIV COLUMBIA

发明人： WASMUTH ANDREW ,  LANDRY DONALD W ,  DENG SHI XIAN ,  RAMASAMY RAVICHANDRAN ,  SCHMIDT ANN MARIE ,  MYLARI BANAVARA L

IPC分类号： C07D231/56 ,  A61K31/519 ,  A61P3/10 ,  C07D487/04

CPC分类号： A61K31/5025 ,  C07D487/04

摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

公开(公告)号：EP1684735A4

公开(公告)日：2009-01-07

申请号：EP04794052

申请日：2004-10-04

申请人： UNIV COLUMBIA

发明人： MARKS ANDREW ROBERT ,  LANDRY DONALD W ,  DENG SHI XIAN ,  CHENG ZHEN ZHUANG

IPC分类号： A61K31/00 ,  A61K20060101 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/68

CPC分类号： G01N33/6893 ,  A61K31/00 ,  G01N33/5076 ,  G01N33/566 ,  G01N33/6887 ,  G01N2333/912 ,  G01N2500/02 ,  G01N2800/325 ,  G01N2800/326

摘要： The present invention provides a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, a method for treating or preventing exercise-induced cardiac arrhythmia in a subject, and a method for preventing exerciseinduced sudden cardiac death in a subject. Also provided are uses of JTV-519 in these methods. The present invention further provides methods for identifying agents for use in preventing exercise-induced sudden cardiac death, as well as agents identified by such methods. Also provided are methods for preventing exercise-induced sudden cardiac death by administering these agents. Additionally, the present invention provides methods for synthesizing JTV-519, radio-labeled JTV-519, and 1,4­benzothiazepine intermediates and derivatives.

公开(公告)号：EP3013339A4

公开(公告)日：2017-01-25

申请号：EP14818293

申请日：2014-06-25

申请人： UNIV COLUMBIA

发明人： KOREN ANDREI O ,  DENG SHI-XIAN ,  LANDRY DONALD W ,  DIVGI CHAITANYA

IPC分类号： A61K31/416 ,  A61K31/40 ,  C07D403/12

CPC分类号： A61K51/0453 ,  C07B59/002 ,  C07B2200/05 ,  C07D403/12

摘要： The present invention relates to the use of compounds that selectively bind to activated protein kinase G 1 alpha for imaging the anatomic basis for chronic pain. Such imaging may also be used to objectively quantify chronic pain.

公开(公告)号：EP2593456A4

公开(公告)日：2013-10-30

申请号：EP11807523

申请日：2011-07-14

申请人： UNIV COLUMBIA

发明人： WASMUTH ANDREW ,  LANDRY DONALD W ,  DENG SHI XIAN ,  RAMASAMY RAVICHANDRAN ,  SCHMIDT ANN MARIE ,  MYLARI BANAVARA L

IPC分类号： C07D487/00

CPC分类号： C07D487/04

公开(公告)号：EP1865978A4

公开(公告)日：2012-01-25

申请号：EP06748487

申请日：2006-03-21

申请人： UNIV COLUMBIA

发明人： AMBRON RICHARD ,  SUNG YING-JU ,  LANDRY DONALD W ,  DENG SHI-ZIAN

IPC分类号： A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10

CPC分类号： A61K38/06 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/352 ,  A61K31/4422 ,  A61K31/55 ,  A61K38/02 ,  A61K38/07 ,  A61K38/465 ,  A61K47/48246 ,  A61K47/64 ,  C12N9/1205 ,  C12Y301/04017

摘要： The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G ("PKG"), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.

公开(公告)号：EP3126332A4

公开(公告)日：2017-09-06

申请号：EP15774440

申请日：2015-03-30

申请人： UNIV COLUMBIA

发明人： ARANCIO OTTAVIO ,  DENG SHIXIAN ,  LANDRY DONALD W ,  FIORITO JOLE ,  PURGATORIO ROSA ,  AMENGUAL JENNIFER EFFIE ,  O'CONNER OWEN ANTHONY

IPC分类号： C07D213/82 ,  C07C235/64

CPC分类号： A61K31/536 ,  A61K31/166 ,  A61K31/403 ,  A61K2121/00 ,  C07C235/42 ,  C07C235/64 ,  C07C237/40 ,  C07D209/34 ,  C07D209/38 ,  C07D265/22 ,  C07D265/26

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

摘要翻译： 本发明提供了包含调节组蛋白酰基转移酶（HAT）的化合物的化合物和组合物。 本发明进一步提供了通过向受试者施用调节HAT的化合物来治疗神经变性病症，与累积的淀粉状蛋白-β肽沉积物相关的病症，Tau蛋白水平和/或α-突触核蛋白蓄积以及癌症的方法。

公开(公告)号：EP3022205A4

公开(公告)日：2016-11-23

申请号：EP14826002

申请日：2014-07-17

申请人： UNIV COLUMBIA

发明人： LANDRY DONALD W ,  DENG SHIXIAN ,  FIORITO JOLE ,  ARANCIO OTTAVIO ,  WASMUTH ANDREW

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D471/14

摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.

公开(公告)号：EP2654428A4

公开(公告)日：2014-08-27

申请号：EP11850544

申请日：2011-12-22

申请人： UNIV COLUMBIA

发明人： FRANCIS YITSHAK ,  FA MAURO ,  ARANCIO OTTAVIO ,  FIORITO JOLE ,  DENG SHIXIAN ,  LANDRY DONALD W ,  LUZAC MICHAL ,  FENG YAN

IPC分类号： A01N55/02

CPC分类号： C07C217/22 ,  C07C217/58 ,  C07C235/60 ,  C07C235/64 ,  C07C251/24 ,  C07D209/48 ,  C07D265/14 ,  C07D265/36 ,  C07D295/088

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.