公开(公告)号：EP2908861A4

公开(公告)日：2016-04-20

申请号：EP13846337

申请日：2013-10-18

申请人： UNIV CORNELL

发明人： PUTNAM DAVID ,  TAN MINGCHEE ,  SAMAROO KIRK J ,  BONASSAR LAWRENCE J

IPC分类号： A61K47/30 ,  A61P19/02

CPC分类号： C10M107/28 ,  A61F2/30756 ,  A61F2002/30673 ,  A61F2002/30754 ,  A61K31/728 ,  A61K31/795 ,  A61K47/48346 ,  A61K47/66 ,  A61L27/3604 ,  A61L27/3695 ,  A61L2400/06 ,  A61L2430/24

摘要： This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol.