公开(公告)号：EP1379885A4

公开(公告)日：2005-07-06

申请号：EP01987446

申请日：2001-12-18

申请人： UNIV DUKE ,  YEDA RES & DEV

发明人： HAROON ZISHAN ,  DEWHIRST MARK W ,  GREENBERG CHARLES S ,  NEEMAN MICHAEL

IPC分类号： A61K49/08 ,  A61K49/14 ,  G01N33/49 ,  A61K51/00 ,  A61M36/14

CPC分类号： A61K49/14 ,  A61K49/085 ,  G01N33/4905

公开(公告)号：EP0705098A4

公开(公告)日：2000-11-22

申请号：EP94917468

申请日：1994-05-23

申请人： APEX BIOSCIENCE INC ,  UNIV DUKE ,  UNIV NORTH CAROLINA STATE

发明人： DEWHIRST MARK W ,  MEYER ROBERT E ,  BONAVENTURA JOSEPH ,  DEANGELO JOSEPH

IPC分类号： A61N5/02 ,  A61F7/00 ,  A61K31/00 ,  A61K31/195 ,  A61K31/198 ,  A61K31/4045 ,  A61K31/42 ,  A61K38/16 ,  A61K38/42 ,  A61K41/00 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00 ,  A61K31/07 ,  A61K31/13 ,  A61K31/135 ,  A61K31/175 ,  A61K31/19 ,  A61K31/20 ,  A61K31/33 ,  A61K31/35 ,  A61K31/47 ,  A61K31/54

CPC分类号： A61K41/0052 ,  A61K31/00 ,  A61K31/195 ,  A61K31/198 ,  A61K31/4045 ,  A61K38/42 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/929 ,  Y10S514/93 ,  A61K2300/00

摘要： The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and oxygenation. The invention is also directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. The invention is also directed to the administration of a nitric oxide synthase substrate to a subject previously administered a nitric oxide synthase inhibitor, in order to selectively inhibit tumor perfusion. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone. In another example, the administration of an inhibitor of nitric oxide synthase followed by the administration of a substrate of the enzyme causes a specific irreversible reduction of tumor blood flow, while normal blood flow is restored.

公开(公告)号：EP2729175A4

公开(公告)日：2015-05-20

申请号：EP12810688

申请日：2012-07-09

申请人： UNIV DUKE ,  IMMUNOLIGHT LLC

发明人： BOURKE FREDERIC A ,  WALDER HAROLD ,  FATHI ZAKARYAE ,  THERIEN MICHAEL J ,  DEWHIRST MARK W ,  STANTON IAN NICHOLAS ,  AYRES JENNIFER ANN ,  FELS DIANE RENEE ,  HERBERT JOSEPH A

IPC分类号： A61K41/00

CPC分类号： A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

公开(公告)号：EP3134122A4

公开(公告)日：2017-12-20

申请号：EP15783728

申请日：2015-04-22

申请人： IMMUNOLIGHT LLC ,  UNIV DUKE ,  UNIV NORTH CAROLINA STATE

发明人： WALDER HAROLD ,  BOURKE FREDERIC A ,  FATHI ZAKARYAE ,  BEYER WAYNE F ,  DEWHIRST MARK W ,  OLDHAM MARK ,  ADAMSON JUSTUS ,  NOLAN MICHAEL

IPC分类号： A61K41/00 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K41/0042 ,  A61K41/0057 ,  A61K49/0423 ,  A61N5/1071 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098

摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 200 kVp, and a plurality of energy-converting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact witht least one photoactivatable agent in the medium. The method introduces the plurality of energy-converting particles into the medium, radiates the energy-converting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 200 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：EP1458397A4

公开(公告)日：2007-03-07

申请号：EP02753472

申请日：2002-08-26

申请人： UNIV DUKE

发明人： STAMLER JONATHAN S ,  PIANTADOSI CLAUDE A ,  DEWHIRST MARK W

IPC分类号： A61K45/00 ,  A61K31/198 ,  A61K31/21 ,  A61K31/223 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P21/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61K31/535

CPC分类号： A61K31/21 ,  A61K31/223 ,  A61K31/5377

公开(公告)号：EP1545627A4

公开(公告)日：2006-12-27

申请号：EP03799374

申请日：2003-10-01

申请人： UNIV DUKE

发明人： LI CHUAN-YUAN ,  HUANG QIAN ,  DEWHIRST MARK W

IPC分类号： A61K48/00 ,  C07K14/075 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C12N5/10 ,  C12N15/85 ,  C12N15/861

CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/2013 ,  A61K38/208 ,  A61K48/00 ,  A61K48/0058 ,  C07K14/4702 ,  C07K14/52 ,  C07K14/525 ,  C12N15/85 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/20

摘要： The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.