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3 条记录 (耗时 0.009 秒)

    ANTIMICROBIAL PEPTIDES.
    1.
    发明公开
    ANTIMICROBIAL PEPTIDES. 失效
    抗微生物多肽。

    公开(公告)号：EP0665754A4

    公开(公告)日：1996-06-12

    申请号：EP93923208

    申请日：1993-10-01

    申请人： UNIV EMORY ,  UNIV GEORGIA RES FOUND

    发明人： SHAFER WILLIAM ,  POHL JAN

    IPC分类号： A61K38/00 ,  A01N37/46 ,  A61P1/02 ,  A61P31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C12N9/64 ,  C12N9/76 ,  C07K14/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C12N9/64 ,  C12N9/6424 ,  C12N9/6427

    摘要： Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad spectrum bactericidal peptide disclosed herein is RPGTLCTVAGWGRVSMRRGT (SEQ ID NO:22). It is active against Pseudomonas aeruginosa, Neisseria gonorrhoeae and Staphylococcus aureus. RRENTQQHITARRAIRHPQY (SEQ ID NO:19) and GKSSGVPPEVFTRFVSSFLPWIRTTMR (SEQ ID NO:26) also exhibited potent activity against P. aeruginosa strains, including clinical isolates. IIGGR (SEQ ID NO:1) and IVGGR (SEQ ID NO:2) act against both gram-negative and gram-positive bacterial strains. HPQYNQR (SEQ ID NO:3) and certain related peptides are also active against both gram-negative and gram-positive bacteria, including, but not limited to, strains of Escherichia coli, Neisseria gonorrhoeae, Staphylococcus aureus, Capnocytophage sputigena and Pseudomonas aeruginosa. The peptides of the present invention will be useful in pharmaceutical compositions useful in the treatment of prophylaxis of infections.